急性肾损伤生物标志物的临床应用前景
Perspective on Clinical Application of Biomarkers in AKI.
作者信息
Parikh Chirag R, Mansour Sherry G
机构信息
Program of Applied Translational Research, Department of Medicine, and
Division of Nephrology, Department of Medicine, Yale University, School of Medicine, New Haven, Connecticut; and.
出版信息
J Am Soc Nephrol. 2017 Jun;28(6):1677-1685. doi: 10.1681/ASN.2016101127. Epub 2017 Feb 20.
Abstract
Several biomarkers of renal injury have been identified but the utility of these biomarkers is largely confined to research studies, whereas widespread clinical applicability is limited. This is partly because the use of serum creatinine as the comparator has several limitations and restricts the full interpretation of biomarker performance. To highlight the potential for clinical application of biomarkers, the most pertinent biomarker data are summarized here, using clinically relevant scenarios in which biomarkers could assist with diagnostic and management dilemmas. The paradigms proposed in this review aim to enhance the clinical diagnosis, management, and prognosis of AKI through the combined use of available clinical markers and novel inflammatory, injury, and repair biomarkers.
摘要
几种肾损伤生物标志物已被识别出来，但这些生物标志物的用途主要局限于研究，而广泛的临床适用性有限。部分原因是将血清肌酐用作对照有几个局限性，限制了对生物标志物性能的全面解读。为突出生物标志物临床应用的潜力，本文总结了最相关的生物标志物数据，采用生物标志物可协助解决诊断和管理难题的临床相关场景。本综述中提出的范例旨在通过联合使用现有的临床标志物以及新型炎症、损伤和修复生物标志物，加强急性肾损伤的临床诊断、管理和预后评估。
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