Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics , 64 Mianshan Road, Mianyang, Sichuan 621900, People's Republic of China.
New Energy Research Institute, School of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Centre , Guangzhou 510006, People's Republic of China.
ACS Appl Mater Interfaces. 2017 Mar 8;9(9):7964-7971. doi: 10.1021/acsami.6b16243. Epub 2017 Feb 27.
A number of oligo-p-phenylene-ethynylenes (OPEs) have exhibited excellent biocidal activity against both Gram-negative and Gram-positive bacteria. Although cell death may occur in the dark, these biocidal compounds are far more effective in the light as a result of their abilities to generate cell-damaging reactive oxygen species. In this study, the interactions of four OPEs with Escherichia coli and Staphylococcus aureus have been investigated. Compared to the OPEs with quaternary ammonium salts (Q-OPE), the OPEs with tertiary ammonium (T-OPE) effectively kill many more bacterial cells under light irradiation, presumably by severe perturbations of the bacterial cell wall and cytoplasmic membrane. According to the findings from this study, such intriguing light-induced antibacterial behavior is probably attributed to the combination of bacterial membrane disruption and the interfacial or intracellular generation of singlet oxygen or other ROS. Singlet oxygen was proved to be formed from irradiation of the OPEs, whereas the varying cell membrane perturbation abilities of OPEs enhance antibacterial activity.
一些寡聚对苯撑乙炔（OPEs）对革兰氏阴性菌和革兰氏阳性菌均表现出优异的杀菌活性。尽管在黑暗中可能会发生细胞死亡，但由于这些杀菌化合物能够产生细胞损伤的活性氧，因此在光照下它们的效果要好得多。在这项研究中，研究了四种 OPE 与大肠杆菌和金黄色葡萄球菌的相互作用。与季铵盐（Q-OPE）相比，具有叔铵（T-OPE）的 OPE 在光照下更有效地杀死了更多的细菌细胞，这可能是由于细菌细胞壁和细胞质膜受到严重干扰。根据这项研究的结果，这种有趣的光诱导抗菌行为可能归因于细菌膜破坏以及界面或细胞内产生单线态氧或其他 ROS 的结合。证明单线态氧是由 OPE 的照射形成的，而 OPE 不同的细胞膜扰动能力增强了抗菌活性。
