Marras Theodore K, Campitelli Michael A, Lu Hong, Chung Hannah, Brode Sarah K, Marchand-Austin Alex, Winthrop Kevin L, Gershon Andrea S, Kwong Jeffrey C, Jamieson Frances B
Emerg Infect Dis. 2017 Mar;23(3):468-476. doi: 10.3201/eid2303.161927.
Survival implications of nontuberculous mycobacterial pulmonary disease (NTM-PD) and NTM pulmonary isolation without disease (NTM-PI) are unclear. To study deaths associated with NTM-PD and NTM-PI and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined NTM-PD or NTM-PI diagnosed during 2001-2013 in Ontario, Canada. We used propensity score matching and Cox proportional hazards models to compare survival. Among 9,681 NTM-PD patients and 10,936 NTM-PI patients, 87% and 91%, respectively, were successfully matched with unexposed controls. Both NTM-PD and NTM-PI were associated with higher rates of death for all species combined and for most individual species. Compared with NTM-PI, NTM-PD was associated with higher death rates for all species combined, Mycobacterium avium complex, and M. xenopi. NTM-PD and NTM-PI were significantly associated with death, NTM-PD more so than NTM-PI.
非结核分枝杆菌肺病（NTM-PD）及无疾病的非结核分枝杆菌肺部定植（NTM-PI）对生存的影响尚不清楚。为研究与NTM-PD和NTM-PI相关的死亡情况以及二者之间生存差异，我们对2001年至2013年期间在加拿大安大略省微生物学确诊为NTM-PD或NTM-PI的人群进行了一项基于人群的队列研究。我们使用倾向评分匹配和Cox比例风险模型来比较生存率。在9681例NTM-PD患者和10936例NTM-PI患者中，分别有87%和91%成功与未暴露对照组进行匹配。NTM-PD和NTM-PI在所有菌种合并及大多数单个菌种中均与较高的死亡率相关。与NTM-PI相比，NTM-PD在所有菌种合并、鸟分枝杆菌复合群及偶发分枝杆菌中与更高的死亡率相关。NTM-PD和NTM-PI均与死亡显著相关，NTM-PD比NTM-PI更甚。
