人类非结核分枝杆菌肺部感染的流行病学：综述
Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review.
作者信息
Prevots D Rebecca, Marras Theodore K
机构信息
Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 15B-1, 8 West Drive, MSC 2665, Bethesda, MD 20892, USA.
Division of Respirology, Department of Medicine, University of Toronto and Toronto Western Hospital, 399 Bathurst Street, 7E-452, Toronto, ON M5T 2S8, Canada.
出版信息
Clin Chest Med. 2015 Mar;36(1):13-34. doi: 10.1016/j.ccm.2014.10.002. Epub 2014 Nov 6.
Abstract
Population-based data have documented a worldwide increase in the prevalence of human nontuberculous mycobacterial (NTM) infections since 2000. Mycobacterium avium complex is predominant in North America and East Asia, whereas in regions within Europe, M kansasii, M xenopi, and M malmoense are more common. Host factors important to the current epidemiology of NTM pulmonary disease include thoracic skeletal abnormalities, rheumatoid arthritis, and use of immunomodulatory drugs. Clustering of disease within families suggests a heritable genetic predisposition to disease susceptibility. Warm, humid environments with high atmospheric vapor pressure contribute to population risk.
摘要
基于人群的数据表明，自2000年以来，全球人类非结核分枝杆菌（NTM）感染的患病率呈上升趋势。鸟分枝杆菌复合体在北美和东亚占主导地位，而在欧洲地区，堪萨斯分枝杆菌、蟾蜍分枝杆菌和马尔默分枝杆菌更为常见。对NTM肺病当前流行病学重要的宿主因素包括胸廓骨骼异常、类风湿性关节炎和免疫调节药物的使用。家族内疾病聚集表明存在对疾病易感性的遗传倾向。大气蒸气压高的温暖潮湿环境会增加人群患病风险。
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