南非和格鲁吉亚耐多药结核病中与吡嗪酰胺耐药相关的pncA基因突变
pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.
作者信息
Allana Salim, Shashkina Elena, Mathema Barun, Bablishvili Nino, Tukvadze Nestani, Shah N Sarita, Kempker Russell R, Blumberg Henry M, Moodley Pravi, Mlisana Koleka, Brust James C M, Gandhi Neel R
出版信息
Emerg Infect Dis. 2017 Mar;23(3):491-495. doi: 10.3201/eid2303.161034.
Abstract
Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.
摘要
虽然吡嗪酰胺常用于结核病治疗，但药物敏感性检测并非常规可用。我们发现，来自南非和格鲁吉亚的70%的耐多药结核分枝杆菌分离株和96%的广泛耐药结核分枝杆菌分离株的pncA基因存在多态性。在将吡嗪酰胺用于耐药结核病治疗方案之前，谨慎评估其药物敏感性或许是明智的。
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