Ionesco M, Baudenon S, Barrasso R, Buu Hoi P, Beuret T, Moniot-Vittoz M, Sadoul G, de Brux J, Coupez F, Orth G
Service de Gynécologie chirurgicale, CHI de Créteil, France.
Bull Cancer. 1987;74(4):397-406.
Cervical biopsies from 66 women presenting an abnormal smear, with HPV related features were studied and histologic features were correlated to the HPV type, as determined by molecular hybridisation studies. HPV DNA sequences were evidenced in 13 of 19 lesions corresponding to exophytic or flat condyloma (HPV type 16 in seven cases, HPV type 11 in four cases, as yet uncharacterized HPV types, HPV X, in two cases). Fourty biopsies were histologically interpreted as CIN, on the basis of atypical mitotic figures (AMF) and/or basal-parabasal cell atypia. HPV type 16 was evidenced in 20 cases (3 cases of double infection: HPV types 16 and 18, HPV types 16 and 33, HPV types 16 and X). In 10 other cases, HPV DNA sequences corresponding to HPV type 11 (one case), HPV 18 (one case) and HPV X (8 cases) were evidenced. In this study, potentially oncogenic HPV types (HPV 16, HPV 18, HPV 33) have been found only in CIN lesions defined on the presence of AMFs and/or basal-parabasal cells atypia. These histologic criteria seem to allow a distinction between low and high risk cervical lesions.
对66名涂片异常且具有HPV相关特征的女性进行了宫颈活检，并将组织学特征与通过分子杂交研究确定的HPV类型相关联。在19个与外生性或扁平湿疣相对应的病变中，有13个检测到HPV DNA序列（7例为HPV 16型，4例为HPV 11型，2例为尚未鉴定的HPV类型，即HPV X）。基于非典型有丝分裂象（AMF）和/或基底-副基底细胞异型性，40份活检组织在组织学上被诊断为CIN。20例检测到HPV 16型（3例为双重感染：HPV 16和18型、HPV 16和33型、HPV 16和X型）。在其他10例中，检测到对应于HPV 11型（1例）、HPV 18型（1例）和HPV X型（8例）的HPV DNA序列。在本研究中，仅在基于存在AMF和/或基底-副基底细胞异型性定义的CIN病变中发现了潜在致癌性HPV类型（HPV 16、HPV 18、HPV 33）。这些组织学标准似乎有助于区分低风险和高风险宫颈病变。
