霍乱毒素对大鼠空肠类花生酸生成的影响。
Effect of cholera toxin on the production of eicosanoids by rat jejunum.
作者信息
Autore G, Capasso F, Di Carlo G, Mascolo N
机构信息
Department of Experimental Pharmacology, University of Naples, Italy.
出版信息
Br J Pharmacol. 1987 Sep;92(1):149-52. doi: 10.1111/j.1476-5381.1987.tb11306.x.
Abstract
1 Cholera toxin injected i.v. into rats stimulated the production of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and LTC4 by segments of jejunum, but it had no effect when added to the tissue in vitro. 2 Pretreatment of the animals with the compound BW 755C reduced the increased production of PGE2, LTB4 and LTC4 by i.v. cholera toxin. Pretreatment with indomethacin reduced the production of PGE2. 3 These findings are consistent with the hypothesis that arachidonate metabolites are involved in the diarrhoea induced by cholera toxin.
摘要
- 静脉注射霍乱毒素至大鼠体内，可刺激空肠段产生前列腺素E2（PGE2）、白三烯B4（LTB4）和LTC4，但在体外将其添加到组织中时则无此作用。2. 用化合物BW 755C对动物进行预处理，可降低静脉注射霍乱毒素引起的PGE2、LTB4和LTC4生成增加。用吲哚美辛预处理可降低PGE2的生成。3. 这些发现与花生四烯酸代谢产物参与霍乱毒素诱导腹泻的假说相符。
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