霍乱毒素对大鼠空肠类花生酸生成的影响。
Effect of cholera toxin on the production of eicosanoids by rat jejunum.
作者信息
Autore G, Capasso F, Di Carlo G, Mascolo N
机构信息
Department of Experimental Pharmacology, University of Naples, Italy.
出版信息
Br J Pharmacol. 1987 Sep;92(1):149-52. doi: 10.1111/j.1476-5381.1987.tb11306.x.
Abstract
1 Cholera toxin injected i.v. into rats stimulated the production of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and LTC4 by segments of jejunum, but it had no effect when added to the tissue in vitro. 2 Pretreatment of the animals with the compound BW 755C reduced the increased production of PGE2, LTB4 and LTC4 by i.v. cholera toxin. Pretreatment with indomethacin reduced the production of PGE2. 3 These findings are consistent with the hypothesis that arachidonate metabolites are involved in the diarrhoea induced by cholera toxin.
摘要
- 静脉注射霍乱毒素至大鼠体内，可刺激空肠段产生前列腺素E2（PGE2）、白三烯B4（LTB4）和LTC4，但在体外将其添加到组织中时则无此作用。2. 用化合物BW 755C对动物进行预处理，可降低静脉注射霍乱毒素引起的PGE2、LTB4和LTC4生成增加。用吲哚美辛预处理可降低PGE2的生成。3. 这些发现与花生四烯酸代谢产物参与霍乱毒素诱导腹泻的假说相符。
相似文献
1
Effect of cholera toxin on the production of eicosanoids by rat jejunum.霍乱毒素对大鼠空肠类花生酸生成的影响。
Br J Pharmacol. 1987 Sep;92(1):149-52. doi: 10.1111/j.1476-5381.1987.tb11306.x.
2
Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals.BW 755c对白三烯B4合成的抑制作用并不会减少尿酸钠晶体诱导的多形核白细胞（PMNL）聚集。
Ann Rheum Dis. 1988 Mar;47(3):241-6. doi: 10.1136/ard.47.3.241.
3
Leukotriene synthesis by human gastrointestinal tissues.人胃肠道组织的白三烯合成
Biochim Biophys Acta. 1986 Sep 12;878(2):184-93. doi: 10.1016/0005-2760(86)90145-1.
4
Eicosanoid formation by mammalian intestine. Effects of some intestinal secretagogues.
Eur J Pharmacol. 1987 Jun 12;138(1):107-13. doi: 10.1016/0014-2999(87)90344-x.
5
Failure of the inhibition of rat gastric mucosal 5-lipoxygenase by novel acetohydroxamic acids to prevent ethanol-induced damage.新型乙酰氧肟酸对大鼠胃黏膜5-脂氧合酶抑制作用未能预防乙醇诱导的损伤。
Br J Pharmacol. 1988 Sep;95(1):155-62. doi: 10.1111/j.1476-5381.1988.tb16559.x.
6
The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation.BW755C及其他抗炎药物对实验性诱导急性炎症中类花生酸浓度和白细胞聚集的影响。
J Pharm Pharmacol. 1983 Dec;35(12):808-13. doi: 10.1111/j.2042-7158.1983.tb02901.x.
7
Modulation by drugs of leukotriene and prostaglandin production from mouse peritoneal macrophages.药物对小鼠腹腔巨噬细胞白三烯和前列腺素生成的调节作用。
Int J Tissue React. 1985;7(2):97-103.
8
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制作用：对急性炎症反应的影响
Br J Pharmacol. 1988 Jun;94(2):547-51. doi: 10.1111/j.1476-5381.1988.tb11559.x.
9
[Features of the effect of leukotriene LTC4 and the blocker of its biosynthesis BW755C on the contractile capability of smooth muscles and the functioning of potential-dependent calcium channels of the nerve cell].[白三烯LTC4及其生物合成阻滞剂BW755C对平滑肌收缩能力及神经细胞电压依赖性钙通道功能的影响特点]
Neirofiziologiia. 1989;21(1):24-31.
10
Effects of non-steroidal anti-inflammatory drugs on rat gastric mucosal leukotriene C4 and prostanoid release: relation to ethanol-induced injury.非甾体抗炎药对大鼠胃黏膜白三烯C4和类前列腺素释放的影响：与乙醇诱导损伤的关系。
Br J Pharmacol. 1988 Apr;93(4):937-43. doi: 10.1111/j.1476-5381.1988.tb11483.x.
引用本文的文献
1
Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139.感染霍乱弧菌O1和O139的儿童和成人体内炎症介质水平升高。
Clin Diagn Lab Immunol. 2002 Mar;9(2):221-9. doi: 10.1128/cdli.9.2.221-229.2002.
本文引用的文献
1
Radioimmunoassay techniques for the determination of the local release of prostaglandins and thromboxanes.用于测定前列腺素和血栓素局部释放的放射免疫分析技术。
J Pharmacol Methods. 1982 May;7(3):207-17. doi: 10.1016/0160-5402(82)90037-7.
2
Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid.花生四烯酸的脂氧合酶代谢产物对结肠分泌的刺激作用。
Science. 1982 Sep 24;217(4566):1255-6. doi: 10.1126/science.6810465.
3
The production of arachidonate lipoxygenase products by rat intestine is increased by phenolphthalein.酚酞可增加大鼠肠道花生四烯酸脂氧合酶产物的生成。
Eur J Pharmacol. 1984 Nov 13;106(2):419-22. doi: 10.1016/0014-2999(84)90732-5.
4
Diarrhea and accumulation of intestinal fluid in infant rabbits infected with Vibrio cholerae in an isolated jejunal segment.
J Infect Dis. 1969 Dec;120(6):645-51. doi: 10.1093/infdis/120.6.645.
5
Cholera and prostaglandins.霍乱与前列腺素。
Nature. 1971 Jun 25;231(5304):536. doi: 10.1038/231536a0.
6
Radioimmunoassay of prostaglandin F-2-alpha in peripheral venous plasma from men and women.男性和女性外周静脉血浆中前列腺素F-2-α的放射免疫测定
Prostaglandins. 1974 Mar 25;5(6):531-42. doi: 10.1016/s0090-6980(74)80028-6.
7
Prevention of cholera-induced intestinal secretion in the cat by aspirin.阿司匹林对猫霍乱诱导的肠道分泌的预防作用。
Nature. 1972 Aug 4;238(5362):273-4. doi: 10.1038/238273a0.
8
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.大鼠体内抗炎剂对霍乱肠毒素的拮抗作用。
Nature. 1972 Jan 21;235(5334):163-5. doi: 10.1038/235163a0.
9
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.前列腺素和霍乱肠毒素对肠黏膜环磷酸腺苷积累的影响。关于前列腺素在毒素作用中起关键作用的证据不足。
J Clin Invest. 1974 Mar;53(3):941-9. doi: 10.1172/JCI107635.
10
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.霍乱肠毒素和前列腺素对肠黏膜腺苷酸环化酶的刺激作用。
J Clin Invest. 1971 Jun;50(6):1218-30. doi: 10.1172/JCI106599.
Zotero 插件