Fischer Andreas, Bossard Matthias, Aeschbacher Stefanie, Egli Peter, Cordewener Carolin, Estis Joel, Todd John, Risch Martin, Risch Lorenz, Conen David
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Clin Chem Lab Med. 2017 Jul 26;55(8):1202-1208. doi: 10.1515/cclm-2016-0920.
Endothelin-1 (ET-1), a vasoconstrictive and pro-inflammatory peptide, is associated with several cardiovascular risk factors and outcomes. We aimed to investigate the association of plasma ET-1 levels and renal function among young and healthy adults.
Individuals aged 25-41 years were enrolled in a population-based cohort study. Main exclusion criteria were established kidney disease, cardiovascular diseases, diabetes mellitus and a body mass index>35 kg/m2. Fasting venous plasma samples were used to measure creatinine, cystatin C and ET-1. The estimated glomerular filtration rate (eGFR) was calculated using the creatinine based chronic kidney disease epidemiology collaboration (CKD-EPI) formula. Multivariable regression models were constructed to assess interrelationships of plasma ET-1 with parameters of renal function.
Median age of the 2139 participants was 37 years, 47% males. Median creatinine and eGFR were 67 μmol/L and 112 mL/min/1.73 m2, respectively. Using quartile one as the reference group, the β-coefficients (95% confidence intervals [CIs]) for eGFR were 0.06 (- 1.22 to 1.35),-0.66 (- 1.95 to 0.62) and-1.70 (- 3.01 to-0.39) for quartiles 2-4 (p-for-trend=0.0056), respectively and β-coefficients (95% CIs) for cystatin C were 0.002 (- 0.01 to 0.02), 0.02 (0.003-0.03) and 0.03 (0.01-0.04) for quartiles 2-4 (p-for-trend<0.0001), respectively. Using ET-1 as a continuous variable, the β-coefficient (95% CI) for eGFR per 1-unit increase was-1.82 (- 3.19 to-0.44, p=0.0095) and 0.02 (0.01-0.04, p=0.0003) for cystatin C. Similar results were found between creatinine and ET-1 levels.
ET-1 levels are strongly associated with parameters of renal function among young and healthy adults, suggesting an important role of ET-1 and endothelial function in the regulation of kidney function.
内皮素-1（ET-1）是一种血管收缩和促炎肽，与多种心血管危险因素及预后相关。我们旨在研究年轻健康成年人血浆ET-1水平与肾功能之间的关联。
年龄在25至41岁的个体纳入一项基于人群的队列研究。主要排除标准为已确诊的肾脏疾病、心血管疾病、糖尿病以及体重指数>35kg/m²。空腹静脉血浆样本用于检测肌酐、胱抑素C和ET-1。采用基于肌酐的慢性肾脏病流行病学协作组（CKD-EPI）公式计算估计肾小球滤过率（eGFR）。构建多变量回归模型以评估血浆ET-1与肾功能参数之间的相互关系。
2139名参与者的中位年龄为37岁，男性占47%。肌酐和eGFR的中位数分别为67μmol/L和112mL/min/1.73m²。以第一四分位数作为参照组，eGFR在第2至4四分位数的β系数（95%置信区间[CI]）分别为0.06（-1.22至1.35）、-0.66（-1.95至0.62）和-1.70（-3.01至-0.39）（趋势p值=0.0056），胱抑素C在第2至4四分位数的β系数（95%CI）分别为0.002（-0.01至0.02）、0.02（0.003至0.03）和0.03（0.01至0.04）（趋势p值<0.0001）。将ET-1作为连续变量，eGFR每增加1个单位的β系数（95%CI）为-1.82（-3.19至-0.44，p=0.0095），胱抑素C为0.02（0.01至0.04，p=0.0003）。在肌酐和ET-1水平之间也发现了类似结果。
年轻健康成年人中ET-1水平与肾功能参数密切相关，提示ET-1和内皮功能在肾功能调节中起重要作用。
