Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
Atherosclerosis. 2015 Mar;239(1):186-91. doi: 10.1016/j.atherosclerosis.2014.12.061. Epub 2015 Jan 14.
Endothelial dysfunction is a major precursor of atherosclerosis. The aim of this study was to assess the interrelationships between plasma endothelin-1 (ET-1) levels and cardiovascular risk among young and healthy individuals.
We performed a population-based study among 2160 healthy adults aged between 25 and 41 years in the Principality of Liechtenstein. Individuals with prevalent cardiovascular disease, diabetes or a body mass index >35 kg/m(2) were excluded. Plasma ET-1 was measured using a novel high-sensitive, single-molecule counting technology. The relationships between plasma levels of ET-1 and various cardiovascular risk factors were assessed by multivariable regression analyses.
Median age of our population was 37 years. Median ET-1 levels across ET-1 quartiles were 1.86, 2.33, 2.76 and 3.48 pg/mL. After multivariable adjustment, there were significant correlations of ET-1 with systolic blood pressure (β per 1-unit increase in log transformed ET-1 2.30 (95% confidence interval (CI) 1.03; 3.58, p = 0.0004), C-reactive protein (β 0.19 (95% CI 0.03; 0.34, p = 0.021), glomerular filtration rate (β -1.73 (95% CI -3.17; -0.29, p = 0.019), and current smoking (Odds ratio 1.94 (95% CI 1.39; 2.71, p < 0.0001). We also found a highly significant association between ET-1 levels and overall cardiovascular risk estimated by the "Prospective Cardiovascular Münster" (PROCAM) and the Framingham score (β 0.18 (95% CI 0.06; 0.31, p = 0.004, and β 0.11 (95% CI 0.05; 0.16), p < 0.0001, respectively).
Plasma ET-1 levels are easily measurable in healthy adults and correlate with major cardiovascular risk factors and global cardiovascular risk.
血管内皮功能障碍是动脉粥样硬化的主要前期病变。本研究旨在评估血浆内皮素-1（ET-1）水平与年轻健康个体心血管风险之间的相互关系。
我们在列支敦士登公国进行了一项基于人群的研究，纳入了 2160 名年龄在 25 至 41 岁之间的健康成年人。排除有明确心血管疾病、糖尿病或体重指数（BMI）>35kg/m2的个体。采用新型高灵敏度、单分子计数技术测量血浆 ET-1。采用多元回归分析评估血浆 ET-1水平与各种心血管危险因素之间的关系。
研究人群的中位年龄为 37 岁。按 ET-1 四分位数分组，ET-1 中位数分别为 1.86、2.33、2.76 和 3.48pg/mL。经多变量调整后，ET-1 与收缩压（每增加 1 个对数转换的 ET-1 单位，β为 2.30[95%置信区间（CI）为 1.03;3.58，p=0.0004]）、C 反应蛋白（β为 0.19[95%CI 为 0.03;0.34，p=0.021]）、肾小球滤过率（β为-1.73[95%CI 为-3.17；-0.29，p=0.019]）和当前吸烟（比值比 1.94[95%CI 为 1.39;2.71，p<0.0001]）呈显著相关。我们还发现 ET-1 水平与“前瞻性心血管明斯特”（PROCAM）和弗雷明汉评分估计的总体心血管风险之间存在高度显著的相关性（β为 0.18[95%CI 为 0.06;0.31，p=0.004]，β为 0.11[95%CI 为 0.05;0.16]，p<0.0001）。
在健康成年人中，血浆 ET-1 水平易于测量，与主要心血管危险因素和整体心血管风险相关。
