Cancer Res. 1987 Nov 1;47(21):5782-7.
The Gambia Hepatitis Intervention Study is a large-scale vaccination project in The Gambia, initiated in July 1986, in which the introduction of national hepatitis B (HBV) vaccination of young infants progressively over a 4-year period is proposed. During this time it is anticipated that about 600,000 infants will receive a course of HBV vaccine and a similar number will not receive the vaccine. All children in the study will receive the normal childhood vaccinations. Identification data for each child will be collected and stored with information on their vaccination records. A national surveillance system will be set up to detect new cases of hepatocellular cancer and other chronic liver diseases over a period of 30 to 40 years. An attempt will be made to trace each case, of relevant age, to determine if they are included in the HBV vaccination study. In this way, the efficacy of HBV vaccine in the prevention of HCC and chronic liver diseases will be evaluated. Details of the study design are discussed.
冈比亚肝炎干预研究是冈比亚的一个大规模疫苗接种项目，于1986年7月启动，该项目提议在4年时间内逐步为年幼婴儿引入全国性乙肝疫苗接种。在此期间，预计约60万名婴儿将接种乙肝疫苗，另有相近数量的婴儿不接种该疫苗。研究中的所有儿童都将接种常规儿童疫苗。将收集每个儿童的识别数据，并与他们的疫苗接种记录信息一起存储。将建立一个国家监测系统，在30至40年的时间里检测肝细胞癌和其他慢性肝病的新病例。将尝试追踪每个相关年龄的病例，以确定他们是否被纳入乙肝疫苗接种研究。通过这种方式，将评估乙肝疫苗在预防肝癌和慢性肝病方面的效果。文中讨论了研究设计的细节。
