Section of Nephrology, Division of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL.
Section of Nephrology, Division of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL.
Am J Kidney Dis. 2017 Jun;69(6):853-857. doi: 10.1053/j.ajkd.2016.12.009. Epub 2017 Feb 20.
A reset osmostat as a cause of hyponatremia can be found in a variety of clinical settings, including pulmonary and neurologic diseases, as well as in physiologic circumstances such as pregnancy. This teaching case describes a 72-year-old white man with a long-standing history of self-medicating with desmopressin acetate (DDAVP) who presented with profound hyponatremia. On discontinuation of DDAVP treatment, he was found to have a reset osmostat. The mild hyponatremia persisted on follow-up. We theorize that the reset osmostat may have developed secondary to long-standing DDAVP use.
重置渗透压感受器可导致低钠血症，这种情况可见于多种临床情况，包括肺部和神经系统疾病，以及生理情况下，如妊娠。本教学病例介绍了一位 72 岁白人男性，他长期自行使用去氨加压素（DDAVP）治疗，此次因严重低钠血症就诊。停用 DDAVP 后，发现其存在重置渗透压感受器。随访时发现患者仍有轻度低钠血症。我们推测重置渗透压感受器可能是由于长期使用 DDAVP 引起的。
