Oxford Centre for Computational Neuroscience, Oxford, UK; Department of Computer Science, University of Warwick, Coventry, UK.
Neurosci Biobehav Rev. 2017 Apr;75:331-334. doi: 10.1016/j.neubiorev.2017.02.013. Epub 2017 Feb 14.
Cortical regions such as the orbitofrontal cortex involved in reward and in non-reward and which are implicated in depression, and the amygdala, are connected to the habenula via the striatum and pallidum, and via subcortical limbic structures. The habenula in turn projects to the raphe nuclei, the source of the serotonin-containing neurons that project to the forebrain. It is proposed that this provides a route for cortical signals related to reward, and to not obtaining expected rewards, to influence the serotonin-containing neuronal system that is influenced by many antidepressant treatments. This helps to provide a more circuit-based understanding of the brain mechanisms related to depression, and how some treatments influence this system. The habenula also projects via the rostromedial tegmental nucleus to the dopamine-containing neurons, and this, it is proposed, provides a route for reward prediction error signals and other reward- and punishment-related signals of cortical and striatal origin to influence the dopamine system.
参与奖励和非奖励过程的皮质区域，如眶额皮质，以及与抑郁有关的杏仁核，通过纹状体和苍白球与缰核相连，并通过皮质下边缘结构相连。缰核反过来投射到中缝核，中缝核是含有 5-羟色胺的神经元的来源，这些神经元投射到前脑。据推测，这为与奖励相关的皮质信号以及未能获得预期奖励的信号提供了一种途径，以影响受许多抗抑郁治疗影响的含 5-羟色胺神经元系统。这有助于提供一种基于回路的更深入的理解与抑郁相关的大脑机制，以及某些治疗方法如何影响这个系统。缰核还通过中脑导水管周围灰质核投射到多巴胺能神经元，据推测，这为来自皮质和纹状体的奖励预测误差信号和其他与奖励和惩罚相关的信号提供了一种途径，以影响多巴胺系统。
