Perdue S T, Terasaki P I, Mickey M R
IARC Sci Publ (1971). 1978(20):263-9.
Frequencies of 25 HLA antigens in 526 Caucasian patients were compared to those in 629 healthy controls who were HLA-typed between September 1975 and February 1977. Haplotypes were compared for 711 patients and 549 controls typed between September 1974 and December 1976. Frequency deviations were found in those with ALL, AML, breast cancer, lymphoma and ovarian cancer, but only the increase in A29 in AML patients was statistically significant when corrected for the number of specificities. Interesting associations, when compared with earlier studies, include elevation of AW24 in both ALL and AML patients and increased B27 in ALL patients. Significant haplotype differences were increased A3-B8 and absence of A1-BW17 in ALL patients and increased A11-B5 and A2-BW40 as well as absence of A2-B5 in AML patients.
将526名白种人患者中25种HLA抗原的频率与1975年9月至1977年2月期间进行HLA分型的629名健康对照者的频率进行了比较。对1974年9月至1976年12月期间分型的711名患者和549名对照者的单倍型进行了比较。在患有急性淋巴细胞白血病（ALL）、急性髓细胞白血病（AML）、乳腺癌、淋巴瘤和卵巢癌的患者中发现了频率偏差，但在校正特异性数量后，只有AML患者中A29频率的增加具有统计学意义。与早期研究相比，有趣的关联包括ALL和AML患者中AW24频率升高以及ALL患者中B27频率增加。显著的单倍型差异包括ALL患者中A3 - B8频率增加和A1 - BW17缺失，以及AML患者中A11 - B5和A2 - BW40频率增加以及A2 - B5缺失。
