Singer Susanne, Jordan Susan, Locati Laura D, Pinto Monica, Tomaszewska Iwona M, Araújo Cláudia, Hammerlid Eva, Vidhubala E, Husson Olga, Kiyota Naomi, Brannan Christine, Salem Dina, Gamper Eva M, Arraras Juan Ignacio, Ioannidis Georgios, Andry Guy, Inhestern Johanna, Grégoire Vincent, Licitra Lisa
Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI)University Medical Center Mainz, Mainz, Germany
University Cancer CentreMainz, Germany.
Endocr Relat Cancer. 2017 Apr;24(4):197-207. doi: 10.1530/ERC-16-0530. Epub 2017 Feb 21.
The purpose of the study was to pilot-test a questionnaire measuring health-related quality of life (QoL) in thyroid cancer patients to be used with the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire EORTC QLQ-C30. A provisional questionnaire with 47 items was administered to patients treated for thyroid cancer within the last 2 years. Patients were interviewed about time and help needed to complete the questionnaire, and whether they found the items understandable, confusing or annoying. Items were kept in the questionnaire if they fulfilled pre-defined criteria: relevant to the patients, easy to understand, not confusing, few missing values, neither floor nor ceiling effects, and high variance. A total of 182 thyroid cancer patients in 15 countries participated ( = 115 with papillary, = 31 with follicular, = 22 with medullary, = 6 with anaplastic, and = 8 with other types of thyroid cancer). Sixty-six percent of the patients needed 15 min or less to complete the questionnaire. Of the 47 items, 31 fulfilled the predefined criteria and were kept unchanged, 14 were removed, and 2 were changed. Shoulder dysfunction was mentioned by 5 patients as missing and an item covering this issue was added. To conclude, the EORTC quality of life module for thyroid cancer (EORTC QLQ-THY34) is ready for the final validation phase IV.
本研究的目的是对一份用于甲状腺癌患者的健康相关生活质量（QoL）调查问卷进行预试验，该问卷将与欧洲癌症研究与治疗组织（EORTC）核心问卷EORTC QLQ-C30一起使用。一份包含47个条目的临时问卷被发放给在过去2年内接受过甲状腺癌治疗的患者。就完成问卷所需的时间和帮助，以及他们是否觉得这些条目易懂、令人困惑或烦人等问题对患者进行了访谈。如果条目符合预先设定的标准，即与患者相关、易于理解、不令人困惑、缺失值少、不存在地板效应和天花板效应且方差大，则保留在问卷中。来自15个国家的182名甲状腺癌患者参与了研究（乳头状癌患者115例，滤泡状癌患者31例，髓样癌患者22例，间变性癌患者6例，其他类型甲状腺癌患者8例）。66%的患者完成问卷需要15分钟或更少时间。在47个条目中，31个符合预定义标准，保持不变，14个被删除，2个被修改。5名患者提到存在肩部功能障碍缺失问题，因此增加了一个涵盖该问题的条目。总之，EORTC甲状腺癌生活质量模块（EORTC QLQ-THY34）已准备好进入最终的IV期验证阶段。
