Priestman S G, Priestman T J, Canney P A
Department of Radiotherapy, Queen Elizabeth Hospital, Birmingham.
Clin Radiol. 1987 Sep;38(5):543-4. doi: 10.1016/s0009-9260(87)80151-4.
Forty patients who were suffering from radiation induced emesis were entered into a prospectively randomised double-blind cross-over study comparing nabilone with metoclopramide. Only patients who had at least five treatments remaining of their planned course of irradiation were randomised, in order to allow an adequate time to monitor the degree of symptom control and any adverse effects of the two drugs. Patient characteristics and the incidence and severity of nausea and vomiting were similar for the two groups. There was no difference in the efficacy of the two drugs but the incidence and severity of adverse reactions was significantly greater in those patients who received nabilone.
40名患有放射性呕吐的患者被纳入一项前瞻性随机双盲交叉研究，该研究比较了纳布啡与甲氧氯普胺。只有那些计划放疗疗程中至少还剩下5次治疗的患者才被随机分组，以便有足够的时间来监测症状控制程度以及两种药物的任何不良反应。两组患者的特征以及恶心和呕吐的发生率及严重程度相似。两种药物的疗效没有差异，但接受纳布啡治疗的患者不良反应的发生率和严重程度明显更高。
