Lewis I H, Campbell D N, Barrowcliffe M P
Department of Anaesthetics, Royal Hampshire County Hospital, Winchester.
Br J Anaesth. 1994 Aug;73(2):244-6. doi: 10.1093/bja/73.2.244.
In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV). Sixty women, less than 70 yr old, undergoing total abdominal hysterectomy, were allocated randomly to receive either nabilone 2 mg or metoclopramide 10 mg orally 90 min before induction of anaesthesia. The study was designed to detect a 50% difference in the incidence of postoperative vomiting between the two groups, with an 80% power of achieving a statistically significant result at the 5% level. Data from 53 patients were analysed: the incidences of nausea and vomiting for the metoclopramide group were 70% and 67%, respectively; the corresponding values for the nabilone group were 73% and 54%. These differences were not significant.
在一项前瞻性双盲研究中，我们研究了术前使用纳布啡对术后恶心和呕吐（PONV）的影响。60名年龄小于70岁、接受全腹子宫切除术的女性被随机分配，在麻醉诱导前90分钟口服2毫克纳布啡或10毫克甲氧氯普胺。该研究旨在检测两组术后呕吐发生率50%的差异，在5%的水平上有80%的把握获得具有统计学意义的结果。对53例患者的数据进行了分析：甲氧氯普胺组恶心和呕吐的发生率分别为70%和67%；纳布啡组的相应值分别为73%和54%。这些差异无统计学意义。
