Pasricha Asha, Bhalla P, Sharma K B
Indian J Dermatol Venereol Leprol. 1979 May-Jun;45(3):159-161.
Fifty strains each of Staphylococcus aureus, beta haemolytic Streptococci, Proteus species, Esch coli and Pseudomonas aeruginosa were subjected to 2%, 1 % and 0. 1 % lactic acid in peptorie water. Minimum inhibitory concentration of lactic acid for all the strains of each of these organisms was 0.1% or 1%. Depending upon its concentration, lactic acid added to peptone water brings down the PH to 2.5-4 which by itself has some inhibitory effect on the microorganisms. Lactic acid however, retains its inhibitory effect even if the Ph of the peptone water is brought back to 7.3. Lactic acid is a nontoxic and non-sensitizing agent because it is a normal metabolite of the body. Thus, it can be used as a safe and effective antibacterial agent for local application.
将金黄色葡萄球菌、β溶血性链球菌、变形杆菌属、大肠杆菌和铜绿假单胞菌各50株置于含2%、1%和0.1%乳酸的蛋白胨水中。这些微生物的所有菌株对乳酸的最低抑菌浓度为0.1%或1%。根据其浓度，添加到蛋白胨水中的乳酸可使pH值降至2.5 - 4，这本身对微生物有一定的抑制作用。然而，即使将蛋白胨水的pH值恢复到7.3，乳酸仍保持其抑制作用。乳酸是一种无毒且无致敏性的物质，因为它是人体的正常代谢产物。因此，它可作为一种安全有效的抗菌剂用于局部应用。
