Akgul Cahit, Kaya Ismet
Canakkale Onsekiz Mart University, Faculty of Arts & Sciences, Department of Chemistry, Terzioglu Campus, 17100 Canakkale, Turkey.
Indian J Biochem Biophys. 2004 Apr-Jun;41(2-3):120-2.
Oligo-3-aminopyridine (OAP) was tested for its antibacterial activity against two gram positive (Staphylococcus aureus and Enterococcus faecalis) and two gram negative (Escherchia coli and Pseudomonas aeruginosa) bacterial strains. Antibacterial efficacy was measured by disk diffusion assay. Inhibition zones demonstrated that 50 microg OAP showed strong antibacterial activity against the gram-positive strains; the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were found to be 25 microg/ml and 50 microg/ml, respectively. The results indicate that OAP is a potent antibacterial agent against S. aureus and E. faecalis.
对寡聚-3-氨基吡啶（OAP）针对两种革兰氏阳性菌（金黄色葡萄球菌和粪肠球菌）以及两种革兰氏阴性菌（大肠杆菌和铜绿假单胞菌）菌株的抗菌活性进行了测试。通过纸片扩散法测定抗菌效力。抑菌圈表明，50微克OAP对革兰氏阳性菌株显示出较强的抗菌活性；最低抑菌浓度（MIC）和最低杀菌浓度（MBC）分别为25微克/毫升和50微克/毫升。结果表明，OAP是一种针对金黄色葡萄球菌和粪肠球菌的强效抗菌剂。
