Morinaga Nobuhiro, Saito Hideyuki, Komine Chika, Matsumoto Asuka, Katoh Toshihide, Tanaka Naritaka, Nakazato Kenji, Nakamura Takuro, Shitara Yoshinori, Ishizaki Masatoshi
Dept. of Surgery, Fujioka General Hospital.
Gan To Kagaku Ryoho. 2017 Feb;44(2):161-164.
A 69-year-old woman underwent proximal gastrectomy with distal pancreatectomy and splenectomy for a gastrointestinal stromal tumor of the stomach.Adjuvant imatinib was administered for a year.Two years after resection of the tumor, liver metastasis in S8 was detected.Therefore, imatinib was re-administered at 300mg/day.After a year of re-administration, the patient suffered muscle cramps in the hands, and therefore imatinib was administered with intervals, such as 4 weeks administration and 4 weeks rest.Re -administration of imatinib was effective and her liver metastasis decreased in size.It was not detected with CT after 1 year and 4 months and remained in complete response(CR)for 3 years and 8 months.After she suffered a brain infarction, imatinib administration was stopped for 4 months.Consequently, the liver metastasis was detectable in S8 again.This clinical course suggested that low-dose and interval administration of imatinib is effective in the treat- ment of GIST.
一名69岁女性因胃胃肠道间质瘤接受了近端胃切除术、远端胰腺切除术和脾切除术。辅助使用伊马替尼治疗一年。肿瘤切除两年后，检测到S8段肝转移。因此，重新给予伊马替尼，剂量为每日300mg。重新给药一年后，患者出现手部肌肉痉挛，因此伊马替尼改为间歇给药，即给药4周，休息4周。伊马替尼重新给药有效，她的肝转移灶缩小。1年4个月后CT未检测到转移灶，完全缓解（CR）状态持续3年8个月。在她发生脑梗死之后，伊马替尼停药4个月。结果，S8段肝转移灶再次被检测到。该临床过程表明，低剂量间歇给药伊马替尼对胃肠道间质瘤的治疗有效。
