Guilbaud Théophile, Ewald Jacques, Turrini Olivier, Delpero Jean Robert
Théophile Guilbaud, Jacques Ewald, Olivier Turrini, Jean Robert Delpero, Department of Surgery, Institut Paoli Calmettes, 13009 Marseille, France.
World J Gastroenterol. 2017 Feb 7;23(5):919-925. doi: 10.3748/wjg.v23.i5.919.
In patients undergoing pancreaticoduodenectomy (PD), unrecognized hemodynamically significant celiac axis (CA) stenosis impairs hepatic arterial flow by suppressing the collateral pathways supplying arterial flow from the superior mesenteric artery and leads to serious hepatobiliary complications due to liver and biliary ischemia, with a high rate of mortality. CA stenosis is usually due to an extrinsic compression by a previously asymptomatic median arcuate ligament (MAL). MAL is diagnosed by computerized tomography in about 10% of the candidates for PD, but only half are found to be hemodynamically significant during the gastroduodenal artery clamping test with Doppler assessment, which is mandatory before any resection. MAL release is usually efficient to restore an adequate liver blood inflow and prevent ischemic complications. In cases of failure in MAL release, postponed PD with secondary stenting of the CA and reoperation for PD should be considered as an alternative to immediate hepatic artery reconstruction, which involves the risk of postoperative thrombosis of the arterial reconstruction. We recently used this two-stage strategy in a patient undergoing surgery for pancreatic adenocarcinoma.
在接受胰十二指肠切除术(PD)的患者中,未被识别的具有血流动力学意义的腹腔干(CA)狭窄会抑制从肠系膜上动脉供应动脉血流的侧支通路,从而损害肝动脉血流,并由于肝脏和胆道缺血导致严重的肝胆并发症,死亡率很高。CA狭窄通常是由先前无症状的正中弓状韧带(MAL)外部压迫所致。在约10%的PD候选患者中,通过计算机断层扫描诊断出MAL,但在使用多普勒评估的胃十二指肠动脉夹闭试验中,只有一半被发现具有血流动力学意义,而该试验在任何切除术前都是必需的。MAL松解通常能有效恢复足够的肝脏血流并预防缺血性并发症。在MAL松解失败的情况下,应考虑延期PD并对CA进行二期支架置入,然后再次进行PD手术,作为直接肝动脉重建的替代方案,因为直接肝动脉重建存在术后动脉重建血栓形成的风险。我们最近在一名接受胰腺腺癌手术的患者中采用了这种两阶段策略。