Saif R, Awan A R, Lyons L, Gandolfi B, Tayyab M, Ellahi Babar M, Wasim M
Department of Biotechnology, Virtual University of Pakistan, Lahore, Pakistan.
Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Iran J Vet Res. 2016 Fall;17(4):231-236.
Current research highlights the based screening of eight cat populations of the world to investigate the association of newly found locus within cat mammary tumors. Total 180 cats were screened on the basis of 4 bp deletion locus (1514-1517del4) which was observed in six mammary tumor cases in Siamese cat breed. Case-control association study revealed the non-significance with P=0.201 and an overall mutant allele frequency of 0.30 ranging from 0.20-0.40 was observed in other cat populations. Similarly, HWE was also obeyed in combined population samples with P=0.860 and found non-significant with range of 0.429-0.708 in other non-Pakistani cat populations as well. These results might be helpful to understand the association of this novel locus in a better way with large sample size of cases and may also serve as a potential marker for mammary tumor diagnosis, particularly in cats and generally in all other animal populations in comparative genetics and genomics context.
当前的研究重点是对全球八个猫种群进行基因座筛查，以调查猫乳腺肿瘤中新发现的基因座之间的关联。基于在暹罗猫品种的六例乳腺肿瘤病例中观察到的4碱基缺失基因座（1514 - 1517del4），总共对180只猫进行了筛查。病例对照关联研究显示无显著性差异，P = 0.201，在其他猫种群中观察到的总体突变等位基因频率为0.30，范围在0.20 - 0.40之间。同样，在合并的种群样本中也符合哈迪 - 温伯格平衡（HWE），P = 0.860，在其他非巴基斯坦猫种群中也无显著性差异，范围在0.429 - 0.708之间。这些结果可能有助于以更好的方式理解这个新基因座与大量病例样本之间的关联，并且在比较遗传学和基因组学背景下，也可能作为乳腺肿瘤诊断的潜在标志物，特别是在猫以及一般所有其他动物种群中。
