妊娠合并高血压疾病时的循环内皮细胞、循环内皮祖细胞和血管性血友病因子
Circulating endothelial cells, circulating endothelial progenitor cells, and von Willebrand factor in pregnancies complicated by hypertensive disorders.
作者信息
Szpera-Goździewicz Agata, Majcherek Maciej, Boruczkowski Maciej, Goździewicz Tomasz, Dworacki Grzegorz, Wicherek Lukasz, Bręborowicz Grzegorz Henryk
机构信息
Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
出版信息
Am J Reprod Immunol. 2017 Mar;77(3). doi: 10.1111/aji.12625.
PROBLEM
We tested the hypothesis that the number of both CECs and CEPCs as well as the vWf blood plasma concentration are altered in pregnant women with hypertensive disorders.
METHOD OF STUDY
Seventy-five pregnant women were enrolled in our study. We used multicolor flow cytometry for CEC and CEPC analysis and the commercial human VWF ELISA kit to measure vWf blood plasma concentration.
RESULTS
The highest number of CECs was found in the chronic hypertension group and the lowest number in the healthy pregnant control group. The highest number of CEPCs was found in the control group and the lowest number in the chronic hypertension group. The vWf blood plasma concentration was the highest in the pre-eclampsia group. The CEPC/CEC ratio reached its lowest value in the chronic hypertension group and its highest value in the control group.
CONCLUSION
The number of both CECs and CEPCs as well as the vWf blood plasma concentration depends on the type of hypertension complicating the pregnancy.
问题
我们检验了以下假设：患有高血压疾病的孕妇体内循环内皮细胞（CECs）和循环内皮祖细胞（CEPCs）的数量以及血管性血友病因子（vWf）血浆浓度均发生了改变。
研究方法
75名孕妇参与了我们的研究。我们使用多色流式细胞术分析CEC和CEPC，并使用商用人类VWF ELISA试剂盒测量vWf血浆浓度。
结果
慢性高血压组的CECs数量最多，健康妊娠对照组的数量最少。对照组的CEPCs数量最多，慢性高血压组的数量最少。子痫前期组的vWf血浆浓度最高。慢性高血压组的CEPC/CEC比值达到最低值，对照组达到最高值。
结论
CECs和CEPCs的数量以及vWf血浆浓度取决于妊娠合并高血压的类型。
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