串扰导向的胚胎学靶点挖掘概念及其在原发性高血压治疗失败中的应用。
The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.
作者信息
Sag Alan Alper, Sal Oguzhan, Kilic Yagmur, Onal Emine Meltem, Kanbay Mehmet
机构信息
Division of Interventional Radiology, Department of Radiology, Koç University School of Medicine, Istanbul, Turkey.
School of Medicine, Koç University, Istanbul, Turkey.
出版信息
J Clin Hypertens (Greenwich). 2017 May;19(5):530-533. doi: 10.1111/jch.12978. Epub 2017 Feb 21.
This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.
本综述旨在介绍应用于器官间串扰网络发生的胚胎学靶点挖掘这一新概念，并将胚胎学靶点挖掘应用于多药耐药性原发性高血压（一种典型的、复杂的、治疗不足的多器官系统综合征），以发现新的治疗靶点，并剖析现有策略失败的原因。简而言之，器官间串扰通路是分子医学靶点挖掘的下一个前沿领域。这是因为刻板的逐步器官发生提供了一个独特的机会来推断可能对发现新治疗靶点至关重要的器官间串扰通路。从本综述中获得的见解将以临床医生指导的方式应用于患者管理。
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