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传统中药通过靶向自发性高血压大鼠细胞外信号调节激酶信号通路抑制左心室肥厚。

Traditional Chinese medicine suppresses left ventricular hypertrophy by targeting extracellular signal-regulated kinases signaling pathway in spontaneously hypertensive rats.

机构信息

Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

出版信息

Sci Rep. 2017 Feb 22;7:42965. doi: 10.1038/srep42965.

DOI:10.1038/srep42965
PMID:28225023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5320505/
Abstract

Chinese herbal medicine Bu-Shen-Jiang-Ya decoction (BSJYD) is reported to be beneficial for hypertension. Over expression of extracellular signal regulated kinases (ERK) pathway plays an important role in left ventricular hypertrophy (LVH). This study aimed to observe effects of BSJYD on LVH in spontaneously hypertensive rats (SHRs) and explore its possible mechanism on regulation of ERK pathway. Sixty 12-week-old SHRs were randomly allocated into 5 groups: BSJYD high dose group, middle dose group, low dose group, captopril group, and control group. Besides, a control group of Wistar-Kyoto rats was established. All rats were treated for 8 weeks. Systolic blood pressure (SBP), heart rate (HR), pathology, and left ventricular mass index (LVMI) were measured. Western blotting and Real-time PCR were used to assess the expressions of BDNF, Ras, ERK1/2, and c-fox levels. SBP and HR were significantly decreased compared with the control group and LVMI was markedly improved by BSJYD treatment in a dose-dependent manner. BSJYD inhibited the expression of BDNF, Ras, ERK1/2, and c-fox mRNA in LVH. In conclusion, BSJYD suppressed hypertension-induced cardiac hypertrophy by inhibiting the expression of ERK pathway. These changes in gene expression may be a possible mechanism by which BSJYD provides myocardial protection from hypertension.

摘要

中药补肾降压汤（BSJYD）对高血压有一定疗效。细胞外信号调节激酶（ERK）通路的过度表达在左心室肥厚（LVH）中起着重要作用。本研究旨在观察 BSJYD 对自发性高血压大鼠（SHR）LVH 的影响，并探讨其对 ERK 通路调节的可能机制。将 60 只 12 周龄 SHR 随机分为 5 组：BSJYD 高、中、低剂量组、卡托普利组和对照组，另设 Wistar-Kyoto 大鼠对照组。所有大鼠均治疗 8 周。测量收缩压（SBP）、心率（HR）、病理学和左心室质量指数（LVMI）。Western blot 和实时 PCR 用于评估 BDNF、Ras、ERK1/2 和 c-fox 水平的表达。与对照组相比，BSJYD 治疗可显著降低 SBP 和 HR，且 LVMI 呈剂量依赖性改善。BSJYD 抑制 LVH 中 BDNF、Ras、ERK1/2 和 c-fox mRNA 的表达。综上所述，BSJYD 通过抑制 ERK 通路的表达抑制高血压引起的心肌肥厚。基因表达的这些变化可能是 BSJYD 为高血压提供心肌保护的一种可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/312ee9e1cda8/srep42965-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/1c5a5dafab68/srep42965-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/46f4c31ec52e/srep42965-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/5b40101cf7fb/srep42965-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/5eda13f48068/srep42965-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/312ee9e1cda8/srep42965-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/1c5a5dafab68/srep42965-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/46f4c31ec52e/srep42965-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/5b40101cf7fb/srep42965-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/5eda13f48068/srep42965-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2774/5320505/312ee9e1cda8/srep42965-f5.jpg

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