Umezaki Yojiro, Uezato Akihito, Toriihara Akira, Nishikawa Toru, Toyofuku Akira
*Psychosomatic Dentistry Clinic, Dental Hospital and Departments of †Psychiatry and Behavioral Sciences, ‡Diagnostic Radiology and Nuclear Medicine, and §Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Clin Neuropharmacol. 2017 Mar/Apr;40(2):97-99. doi: 10.1097/WNF.0000000000000207.
Oral cenesthopathy is the complaint of abnormal oral sensation where no underlying organic cause can be identified. It is also called oral dysesthesia or oral somatic delusion and classified as delusional disorder, somatic type. The patients with oral cenesthopathy show right > left asymmetric regional cerebral blood flow (rCBF) in the broad brain region. However, the studies scrutinizing the rCBF change before and after the successful treatment are still a few so far.
We present 2 cases of oral cenesthopathy, who responded well to aripiprazole. The asymmetric rCBF patterns were attenuated after successful treatment in both cases.
We found a marked improvement of oral cenesthopathy with aripiprazole. It is suggested that right > left rCBF asymmetry in the frontal and temporal lobes and thalamus, and the dopaminergic and serotonergic dysfunctions are involved in the pathology of oral cenesthopathy.
口腔感觉异常是指在无法确定潜在器质性病因的情况下出现的口腔异常感觉。它也被称为口腔感觉障碍或口腔躯体妄想，归类为妄想障碍，躯体型。口腔感觉异常患者在广泛的脑区表现出右侧>左侧不对称的局部脑血流（rCBF）。然而，迄今为止，对成功治疗前后rCBF变化进行仔细研究的仍为数不多。
我们报告2例口腔感觉异常患者，他们对阿立哌唑反应良好。在两例患者成功治疗后，不对称的rCBF模式均有所减轻。
我们发现阿立哌唑可显著改善口腔感觉异常。提示额叶、颞叶和丘脑的右侧>左侧rCBF不对称以及多巴胺能和5-羟色胺能功能障碍与口腔感觉异常的病理机制有关。
