Department of Neuropsychiatry, Toho University School of Medicine, Ota-ku, Tokyo, Japan.
Psychiatry Clin Neurosci. 2011 Oct;65(6):600-3. doi: 10.1111/j.1440-1819.2011.02257.x.
The purpose of the present study was to investigate regional cerebral blood flow (rCBF) changes in a patient with very-late-onset schizophrenia-like psychosis (VLOS) with catatonia. A 64-year-old woman developed catatonia after experiencing persecutory delusions. The patient's rCBF was examined using single photon emission computed tomography (SPECT) with easy Z-score imaging system. Before treatment, hypoperfusion was observed in the striatum and the thalamus, whereas hyperperfusion was observed in the left lateral frontal cortex and the left temporal cortex. After treatment, the disproportions in rCBF disappeared, and hyperperfusion was observed in the motor cortex. Sequential SPECT findings suggest that rCBF abnormalities may be correlated with the symptomatology of catatonia in patients with VLOS.
本研究旨在探讨一例伴有紧张症的极晚发性精神分裂样精神病（VLOS）患者的局部脑血流（rCBF）变化。一位 64 岁女性在出现被害妄想后出现紧张症。使用单光子发射计算机断层扫描（SPECT）和简易 Z 评分成像系统对患者的 rCBF 进行了检查。治疗前，纹状体和丘脑呈低灌注，而左侧额外侧皮质和左侧颞叶皮质呈高灌注。治疗后，rCBF 的不均衡消失，运动皮质呈高灌注。连续 SPECT 发现提示 rCBF 异常可能与 VLOS 患者紧张症的症状相关。
