Shim Young Suk, Kang Min Jae, Oh Yeon Jeong, Baek Joon Woo, Yang Seung, Hwang Il Tae
Department of Pediatrics, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea.
Medicine (Baltimore). 2017 Feb;96(8):e6179. doi: 10.1097/MD.0000000000006179.
This study aimed to evaluate the associations of serum ferritin with insulin resistance indices, body fat mass/percentage, and all the components of metabolic syndrome (MetS), as well as the risk for MetS according to serum ferritin levels in Korean adolescents and adults.A total of 15,963 Korean males and females aged 16 to 80 years were analyzed using data from the Korean National Health and Nutrition Examination Survey, 2005 to 2011.The median serum ferritin concentration was 98.82 ng/mL for males and 38.60 ng/mL for females (P < 0.001). Increased risks of greater waist circumference and elevated glucose levels, elevated triglyceride levels, and reduced high-density lipoprotein cholesterol levels were noted across the serum ferritin quartiles after adjustment for confounders in both genders (P ≤ 0.012 for trend). Insulin resistance indices and abdominal obesity (trunk fat mass/percent) increased across the ferritin concentration quartiles after adjustment for confounders in males and females (P ≤ 0.011 for trend), and the risk of MetS increased across the ferritin quartiles in males (P < 0.001 for trend) and females (P = 0.001 for trend). The highest serum ferritin quartile exhibited a 1.62-fold increased risk of MetS (95% CI, 1.28-2.12) in males and a 1.36-fold increased risk of MetS (95% CI, 1.09-1.69) in females compared with the lowest quartile after adjustment for confounders.Our results suggest that ferritin is associated with insulin resistance and abdominal obesity.
本研究旨在评估韩国青少年和成年人血清铁蛋白与胰岛素抵抗指数、体脂量/百分比、代谢综合征（MetS）所有组分之间的关联，以及根据血清铁蛋白水平得出的MetS风险。利用2005年至2011年韩国国家健康与营养检查调查的数据，对总共15963名年龄在16至80岁的韩国男性和女性进行了分析。男性血清铁蛋白浓度中位数为98.82 ng/mL，女性为38.60 ng/mL（P<0.001）。在对两性混杂因素进行校正后，血清铁蛋白四分位数范围内均观察到腰围增加、血糖水平升高、甘油三酯水平升高和高密度脂蛋白胆固醇水平降低的风险增加（趋势P≤0.012）。在对男性和女性混杂因素进行校正后，胰岛素抵抗指数和腹部肥胖（躯干脂肪量/百分比）在铁蛋白浓度四分位数范围内均增加（趋势P≤0.011），男性（趋势P<0.001）和女性（趋势P=0.001）MetS风险在铁蛋白四分位数范围内均增加。在校正混杂因素后，血清铁蛋白最高四分位数的男性MetS风险比最低四分位数增加了1.62倍（95%CI，1.28 - 2.12），女性增加了1.36倍（95%CI，1.09 - 1.69）。我们的结果表明，铁蛋白与胰岛素抵抗和腹部肥胖有关。
