Yan Chen, Luo Lan, Urata Yoshishige, Goto Shinji, Guo Chang-Ying, Li Tao-Sheng
a Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
b Department of Thoracic Surgery, Jiangxi Cancer Hospital, Nanchang, 330029, China.
Radiat Res. 2017 Feb 22. doi: 10.1667/RR14614.1.
Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation-induced injury. We investigated the role of nicaraven in cancer cells and tumor growth. While nicaraven did not significantly change the colony-forming abilities and DNA damage levels in several cancer cell lines after irradiation, it significantly protected mouse bone marrow-derived hematopoietic stem cells from radiation injury. In established mouse tumor models in which radiation exposure significantly inhibited the growth of tumors, nicaraven did not significantly mitigate the radiation-induced inhibition of tumor growth. The results of this study showed that while nicaraven attenuated the toxicity of radiotherapy in hematopoietic stem cells, it had very limited effects on the survival of cancer cells and tumor growth. Nicaraven may be an ideal drug for mitigating the side effects of radiotherapy in patients with cancer.
放射疗法是治疗多种癌症的主要方法之一，然而，它受到一些患者所经历的严重副作用和并发症的限制。尼卡雷文是一种化学合成的羟基自由基特异性清除剂，已被证明可保护正常组织免受辐射诱导的损伤。我们研究了尼卡雷文在癌细胞和肿瘤生长中的作用。虽然尼卡雷文在照射后并未显著改变几种癌细胞系的集落形成能力和DNA损伤水平，但它能显著保护小鼠骨髓来源的造血干细胞免受辐射损伤。在已建立的小鼠肿瘤模型中，辐射暴露显著抑制肿瘤生长，而尼卡雷文并未显著减轻辐射诱导的肿瘤生长抑制。本研究结果表明，虽然尼卡雷文减轻了放射疗法对造血干细胞的毒性，但对癌细胞存活和肿瘤生长的影响非常有限。尼卡雷文可能是减轻癌症患者放射疗法副作用的理想药物。
