Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Cancer Lett. 2018 Apr 1;418:204-210. doi: 10.1016/j.canlet.2018.01.037. Epub 2018 Jan 13.
Radiotherapy for cancer patients damages normal tissues, thereby inducing an inflammatory response and promoting cancer metastasis. We investigated whether nicaraven, a compound with radioprotective and anti-inflammatory properties, could attenuate radiation-induced cancer metastasis to the lungs of mice. Nicaraven and amifostine, another commercial radioprotective agent, had limited effects on both the radiosensitivity of Lewis lung carcinoma cells in vitro and radiation-induced tumor growth inhibition in vivo. Using experimental and spontaneous metastasis models, we confirmed that thorax irradiation with 5 Gy X-rays dramatically increased the number of tumors in the lungs. Interestingly, the number of tumors in the lungs was significantly reduced by administering nicaraven but not by administering amifostine daily after radiation exposure. Furthermore, nicaraven administration effectively inhibited CCL8 expression and macrophage recruitment in the lungs 1 day after thorax irradiation. Our data suggest that nicaraven attenuates radiation-induced lung metastasis, likely by regulating the inflammatory response after radiation exposure.
放射疗法会损害癌症患者的正常组织，从而引发炎症反应并促进癌症转移。我们研究了具有放射防护和抗炎特性的化合物尼卡瑞韦是否可以减轻放射诱导的小鼠肺部癌症转移。尼卡瑞韦和另一种商业放射防护剂氨磷汀对体外 Lewis 肺癌细胞的放射敏感性和体内放射诱导的肿瘤生长抑制作用有限。通过实验和自发转移模型，我们证实，5Gy X 射线胸部照射显著增加了肺部肿瘤的数量。有趣的是，尼卡瑞韦给药可显著减少肺部肿瘤的数量，但氨磷汀给药则无此效果。此外，尼卡瑞韦给药可有效抑制胸部照射后 1 天肺部 CCL8 表达和巨噬细胞募集。我们的数据表明，尼卡瑞韦通过调节放射后炎症反应来减轻放射诱导的肺转移。
