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CD30阳性皮肤淋巴瘤:4例报告并着重探讨临床病理相关性

CD30-positive cutaneous lymphoma: report of four cases with an emphasis on clinicopathological correlations.

作者信息

Vargas Thiago Jeunon de Sousa, Jorge Samira Barroso, Gonzaga Yung Bruno de Mello

机构信息

Hospital Federal de Bonsucesso - Bonsucesso (RJ), Brazil.

Instituto Nacional de Câncer (INCA) - Rio de Janeiro (RJ), Brazil.

出版信息

An Bras Dermatol. 2017 Jan-Feb;92(1):86-91. doi: 10.1590/abd1806-4841.20174807.

DOI:10.1590/abd1806-4841.20174807
PMID:28225962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5312184/
Abstract

The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, and mycosis fungoides with large cell transformation, highlighting the importance of clinicopathological correlation to classify these cases.

摘要

皮肤淋巴瘤的分类是多学科的,需要临床、组织病理学、免疫组织化学和分子诊断要素之间的相互关联。在本文中,我们展示了4例伴有皮肤表现的CD30阳性T细胞淋巴瘤的不同病例。我们将这些病例与淋巴样丘疹病C型、原发性皮肤间变性大T细胞淋巴瘤、伴有继发性皮肤受累的系统性间变性大T细胞淋巴瘤以及伴有大细胞转化的蕈样肉芽肿的确诊病例进行比较,强调了临床病理相关性在这些病例分类中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/7de8b79724f8/abd-92-01-0086-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/b4d67f30a3de/abd-92-01-0086-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/68f2a402f868/abd-92-01-0086-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/812ef5d7da5f/abd-92-01-0086-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/72808da278f6/abd-92-01-0086-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/da106df3f511/abd-92-01-0086-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/737c87f8a095/abd-92-01-0086-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/719c3fa4e815/abd-92-01-0086-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/7de8b79724f8/abd-92-01-0086-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/b4d67f30a3de/abd-92-01-0086-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/68f2a402f868/abd-92-01-0086-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/812ef5d7da5f/abd-92-01-0086-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/72808da278f6/abd-92-01-0086-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/da106df3f511/abd-92-01-0086-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/737c87f8a095/abd-92-01-0086-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/719c3fa4e815/abd-92-01-0086-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239f/5312184/7de8b79724f8/abd-92-01-0086-gf08.jpg

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Brentuximab as a treatment for CD30+ mycosis fungoides and Sézary syndrome.本妥昔单抗治疗 CD30+蕈样肉芽肿和赛泽里综合征。
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Cutaneous lymphomas: an update. Part 1: T-cell and natural killer/t-cell lymphomas and related conditions.皮肤淋巴瘤:最新进展。第1部分:T细胞和自然杀伤/T细胞淋巴瘤及相关疾病。
Am J Dermatopathol. 2014 Feb;36(2):105-23. doi: 10.1097/DAD.0b013e318289b1db.
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