A型肉毒杆菌毒素治疗面肌痉挛：疗效显著、持久且耐受性良好。
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated.
作者信息
Batisti Jean Pierre Mette, Kleinfelder Alais Daiane Fadini, Galli Natália Bassalobre, Moro Adriana, Munhoz Renato Puppi, Teive Hélio Afonso Ghizoni
机构信息
Universidade Federal do Paraná, Hospital de Clínicas, Curitiba PR, Brasil.
Universidade Federal do Paraná, Hospital de Clínicas, Unidade de Distúrbios do Movimento, Departamento de Medicina Interna, Serviço de Neurologia, Curitiba PR, Brasil.
出版信息
Arq Neuropsiquiatr. 2017 Feb;75(2):87-91. doi: 10.1590/0004-282X20160191.
OBJECTIVE
To evaluate the long-term effect of botulinum toxin type A (BTX-A) in the treatment of HFS.
METHODS
A retrospective analysis of patients treated at the Movement Disorders Outpatient Clinic in the Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, from 2009 to 2013 was carried out. A total of 550 BTX-A injections were administered to 100 HFS patients.
RESULTS
Mean duration of improvement following each injection session was 3.1 months, mean latency to detection of improvement was 7.1 days and mean success rate was 94.7%. Patients were evaluated at an interval of 5.8 months after each application. Adverse effects, which were mostly minor, were observed in 37% of the patients at least once during follow-up. The most frequent was ptosis (35.1%).
CONCLUSION
Treatment of HFS with BTX-A was effective, sustainable and safe and had minimal, well-tolerated side effects.
目的
评估A型肉毒毒素（BTX-A）治疗面肌痉挛（HFS）的长期效果。
方法
对2009年至2013年在库里蒂巴巴拉那联邦大学临床医院神经科运动障碍门诊接受治疗的患者进行回顾性分析。共对100例面肌痉挛患者进行了550次A型肉毒毒素注射。
结果
每次注射后改善的平均持续时间为3.1个月，改善的平均检测潜伏期为7.1天，平均成功率为94.7%。每次注射后间隔5.8个月对患者进行评估。在随访期间，37%的患者至少出现过一次不良反应，且大多为轻微不良反应。最常见的是上睑下垂（35.1%）。
结论
A型肉毒毒素治疗面肌痉挛有效、可持续且安全，副作用极小且耐受性良好。
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