Shannon I L, Edmonds E J
Int Dent J. 1978 Dec;28(4):421-6.
An evaluation was made of the effect of different concentrations of F on the ability of OraLube, a saliva substitute developed by the Veterans Administration designed for use by xerostomic patients, to reharden enamel surfaces. Test preparations contained either 0, 1.0, 2.0, 3.0, 4.0 or 5.0 ppm and groups of softened enamel surfaces were treated with these solutions for 30 minutes. Treatment with saliva substitute containing no F did not significantly alter the hardness of enamel surfaces. Including 1.0 ppm F in the formula induced a rehardening of about 5 per cent; 2.0 ppm F solution rehardened at a 12.5 per cent rate. Additional F up to 5.0 ppm did not increase rehardening significantly. The inclusion of 2.0 ppm F in OraLube assures that, in addition to its ability to relieve intraoral soft tissue problems associated with xerostomia, an optimal rehardening potential is provided.
对不同浓度的氟（F）对OraLube（退伍军人管理局开发的一种供口干症患者使用的唾液替代品）使牙釉质表面再次硬化能力的影响进行了评估。测试制剂含有0、1.0、2.0、3.0、4.0或5.0 ppm的氟，用这些溶液对软化的牙釉质表面组进行30分钟的处理。用不含氟的唾液替代品处理不会显著改变牙釉质表面的硬度。配方中含1.0 ppm氟可使牙釉质表面再次硬化约5%；2.0 ppm氟溶液的再次硬化率为12.5%。高达5.0 ppm的额外氟不会显著增加再次硬化程度。在OraLube中加入2.0 ppm氟可确保，除了能够缓解与口干症相关的口腔软组织问题外，还能提供最佳的再次硬化潜力。
