Department of Pharmaceutical Botany, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Department of Pharmacognosy, Faculty of Pharmacy, Université d la Méditerranée, Marseille, France.
Curr Pharm Des. 2017;23(17):2414-2421. doi: 10.2174/1381612823666170220155540.
Compounds and extracts derived from natural sources continue to stand in the spotlight of drug design owing to their versatile interaction with enzymes, receptors and metabolic pathways. Nanomedicine offers an operative tool for the efficient delivery of natural products, in terms of increased bioavailability, targeting, and controlled release while protecting active constituents against physico-chemical alterations. The interest of the scientific community in the field of nanosized delivery of natural compounds is demonstrated by the exponential growth of the publications in this field.
Beyond the presentation of successful examples of nanoscale delivery systems containing natural products, the scope of this review is to point out the yet underexplored capacities of this field with relevance for the pharmaceutical and nutraceutical market.
Departing from a short presentation of plant-derived natural products and strategies to obtain nanoformulations, the current work discusses nanoparticulate drug delivery systems targeting diseases of various organs and systems: skin, central nervous system, skeletal tissue, cardiovascular apparatus, and diabetes.
While notable progress has been achieved in the preparation of nanomedicines containing selected dietary polyphenols, works dealing with crude extracts or standardized fractions are much less frequent. In fact, most of the plants with solidly documented therapeutic properties and registered in pharmacopoeias still wait to benefit from advances in the field of nanotechnology. At least for some of them, adequate nanoformulation shall contribute to their removal from the group of dietary supplements and pharmaceutical preparations with suboptimal bioavailability and efficacy.
由于天然来源的化合物和提取物与酶、受体和代谢途径具有多种相互作用，因此它们仍然是药物设计的焦点。纳米医学为有效输送天然产物提供了一种操作工具，可提高生物利用度、靶向性和控制释放，同时保护有效成分免受物理化学变化的影响。科学界对纳米尺度输送天然化合物领域的兴趣体现在该领域出版物的指数级增长上。
本综述不仅介绍了含有天然产物的纳米递药系统的成功实例，还指出了该领域尚未得到充分探索的潜力，这些潜力与制药和营养保健品市场相关。
本综述从植物来源的天然产物和获得纳米制剂的策略的简要介绍开始，讨论了针对各种器官和系统疾病的纳米颗粒药物递送系统：皮肤、中枢神经系统、骨骼组织、心血管系统和糖尿病。
虽然在制备含有选定膳食多酚的纳米药物方面取得了显著进展，但涉及粗提取物或标准化部分的工作要少得多。事实上，具有确凿治疗特性并在药典中注册的大多数植物仍有待受益于纳米技术领域的进步。至少对于其中一些植物来说，适当的纳米制剂将有助于它们从膳食补充剂和生物利用度和疗效不佳的药物制剂中去除。
