硫代苹果酸金钠对感染披膜病毒和黄病毒的成年瑞士/A2G小鼠的影响。
The effect of gold sodium thiomalate in adult Swiss/A2G mice infected with togaviruses and flaviviruses.
作者信息
Mehta S, Webb H E
机构信息
Neurovirology Unit, Rayne Institute, London, U.K.
出版信息
J Gen Virol. 1987 Oct;68 ( Pt 10):2665-8. doi: 10.1099/0022-1317-68-10-2665.
PMID:2822844
Abstract
Treatment of adult mice with gold sodium thiomalate made the normally non-lethal Semliki Forest virus and Sindbis virus infections lethal and increased the virulence of Langat and West Nile viruses. These changes were associated with an enhanced virus invasion of the brain. Depression of the humoral antibody response was not observed.
摘要
用硫代苹果酸钠金处理成年小鼠，会使通常无致死性的塞姆利基森林病毒和辛德毕斯病毒感染变得具有致死性，并增强兰加特病毒和西尼罗河病毒的毒力。这些变化与病毒对大脑的侵袭增强有关。未观察到体液抗体反应受到抑制。
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