Amor S, Webb H E
Neurovirology Unit, Rayne Institute, United Medical Schools, Guy's Hospital, London, UK.
Br J Exp Pathol. 1988 Apr;69(2):197-208.
Mice inoculated intraperitoneally with the alphavirus Semliki Forest were protected against a subsequent challenge with the flavivirus Langat. The protection was seen as a reduction in the Langat virus titres, mortality index and percentage deaths. The severity of the brain pathology was greater in the simultaneously infected mice, or when the time interval between administration of the viruses was 7 days, compared to that seen following a single infection of either Semliki Forest or Langat virus. When the time interval was greater than 14 days the severity of the histopathological lesions were reduced. Two factors were considered to be of possible importance in the protection afforded by the original alphavirus. Either persistence of the alphavirus interfering with the challenge flavivirus or cross-reactive immunity arising from a common host cell membrane derived glycolipid component present in both viral envelopes. This latter phenomenon could be important as anti-glycolipid activity present at 14 days after the first virus increased significantly after challenge with the second virus.
经腹腔接种辛德毕斯病毒的小鼠对随后接种的兰加特病毒具有抵抗力。这种抵抗力表现为兰加特病毒滴度降低、死亡率指数和死亡百分比降低。与单独感染辛德毕斯病毒或兰加特病毒相比，同时感染的小鼠或两种病毒接种时间间隔为7天时，脑病理学严重程度更高。当时间间隔大于14天时，组织病理学损伤的严重程度降低。对于最初的甲病毒所提供的抵抗力，有两个因素可能很重要。要么是甲病毒持续存在干扰了攻击的黄病毒，要么是由两种病毒包膜中存在的共同宿主细胞膜衍生糖脂成分产生的交叉反应性免疫。后一种现象可能很重要，因为在第一次病毒感染后14天出现的抗糖脂活性在第二次病毒攻击后显著增加。
