Live-Cell Imaging Reveals Tau Isoforms Imbalance Disrupts Traffic of APP Vesicles in Human Neurons.
作者信息
Hung Christy Oi Ying
机构信息
Signalling Programme, Babraham Institute, University of Cambridge, Cambridge CB22 3AT, United Kingdom
出版信息
J Neurosci. 2017 Feb 22;37(8):1968-1970. doi: 10.1523/JNEUROSCI.3688-16.2017.
Abstract
摘要
相似文献
1
Live-Cell Imaging Reveals Tau Isoforms Imbalance Disrupts Traffic of APP Vesicles in Human Neurons.活细胞成像揭示tau异构体失衡扰乱人类神经元中淀粉样前体蛋白囊泡的运输。
J Neurosci. 2017 Feb 22;37(8):1968-1970. doi: 10.1523/JNEUROSCI.3688-16.2017.
2
Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons.tau蛋白异构体失衡损害人类神经元中淀粉样前体蛋白的轴突运输。
J Neurosci. 2017 Jan 4;37(1):58-69. doi: 10.1523/JNEUROSCI.2305-16.2016.
3
Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.源自散发性阿尔茨海默病 iPSC 的神经元显示出 TAU 过度磷酸化增加、淀粉样蛋白水平升高和 GSK3β 激活。
Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z.
4
Key Peptides and Proteins in Alzheimer's Disease.阿尔茨海默病相关的关键肽和蛋白
Curr Protein Pept Sci. 2019;20(6):577-599. doi: 10.2174/1389203720666190103123434.
5
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress.tau蛋白会阻碍神经元中细胞器、神经丝和淀粉样前体蛋白囊泡的运输，并增强氧化应激。
J Cell Biol. 2002 Mar 18;156(6):1051-63. doi: 10.1083/jcb.200108057.
6
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.tau蛋白对APP转运的抑制作用不会增加β淀粉样肽的生成。
Traffic. 2006 Jul;7(7):873-88. doi: 10.1111/j.1600-0854.2006.00434.x. Epub 2006 May 25.
7
Heat-shocked neuronal PC12 cells reveal Alzheimer's disease--associated alterations in amyloid precursor protein and tau.热休克神经元PC12细胞显示出与阿尔茨海默病相关的淀粉样前体蛋白和tau蛋白改变。
Ann N Y Acad Sci. 1993 Sep 24;695:194-7. doi: 10.1111/j.1749-6632.1993.tb23051.x.
8
Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.淀粉样前体蛋白（APP）的果蝇同源物APPL在神经元中的过表达会破坏轴突运输。
Curr Biol. 1999 May 6;9(9):489-92. doi: 10.1016/s0960-9822(99)80215-2.
9
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.阿尔茨海默病中的老年斑神经突会积累淀粉样前体蛋白。
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7552-6. doi: 10.1073/pnas.88.17.7552.
10
Differential expression of beta amyloid protein precursor (APP) and tau mRNA in the aged human brain: individual variability and correlation between APP-751 and four-repeat tau.
J Neuropathol Exp Neurol. 1991 Sep;50(5):560-78. doi: 10.1097/00005072-199109000-00004.
引用本文的文献
1
Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes.星形胶质细胞中与神经退行性变相关蛋白的内体溶酶体加工。
Int J Mol Sci. 2020 Jul 21;21(14):5149. doi: 10.3390/ijms21145149.
本文引用的文献
1
Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons.tau蛋白异构体失衡损害人类神经元中淀粉样前体蛋白的轴突运输。
J Neurosci. 2017 Jan 4;37(1):58-69. doi: 10.1523/JNEUROSCI.2305-16.2016.
2
Tau in physiology and pathology.tau 在生理学和病理学中的作用。
Nat Rev Neurosci. 2016 Jan;17(1):5-21. doi: 10.1038/nrn.2015.1. Epub 2015 Dec 3.
3
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.小鼠P301L tau基因敲入神经元中轴突线粒体数量减少及tau蛋白低磷酸化
Neurobiol Dis. 2016 Jan;85:1-10. doi: 10.1016/j.nbd.2015.10.007. Epub 2015 Oct 11.
4
Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.人突变 P301S 微管相关蛋白 tau 转基因小鼠轴突运输减少和兴奋性毒性视网膜神经节细胞变性。
PLoS One. 2012;7(4):e34724. doi: 10.1371/journal.pone.0034724. Epub 2012 Apr 4.
5
Modelling early responses to neurodegenerative mutations in mice.在小鼠中模拟神经退行性突变的早期反应。
Biochem Soc Trans. 2011 Aug;39(4):933-8. doi: 10.1042/BST0390933.
6
Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.在“P301L”tau 敲入小鼠中，与年龄相关的轴突运输和运动变化以及 tau 去磷酸化。
Neurobiol Aging. 2012 Mar;33(3):621.e1-621.e15. doi: 10.1016/j.neurobiolaging.2011.02.014. Epub 2011 Apr 13.
7
Amyloid precursor protein processing and Alzheimer's disease.淀粉样前体蛋白的加工与阿尔茨海默病。
Annu Rev Neurosci. 2011;34:185-204. doi: 10.1146/annurev-neuro-061010-113613.
8
Transgenic mouse models of tauopathy in drug discovery.用于药物研发的 Tau 病转基因小鼠模型。
CNS Neurol Disord Drug Targets. 2010 Aug;9(4):403-28. doi: 10.2174/187152710791556131.
9
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.额颞叶痴呆小鼠模型中的帕金森综合征与轴突运输受损
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15997-6002. doi: 10.1073/pnas.0808084105. Epub 2008 Oct 2.
10
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.阿尔茨海默病及相关疾病中tau蛋白介导的神经退行性变。
Nat Rev Neurosci. 2007 Sep;8(9):663-72. doi: 10.1038/nrn2194.
Zotero 插件