Ishida H, Shimamoto K, Ando T, Nishitani T, Hosoda S, Yokoyama T, Yamaji I, Iimura O
Second Department of Internal Medicine, Sapporo Medical College, Japan.
J Clin Hypertens. 1987 Sep;3(3):257-61.
To investigate the relationship between plasma kinin and the sympathetic nervous system, we measured plasma kinin, norepinephrine, and angiotensin-I-converting enzyme (ACE:kininase II) activity in normal subjects. In six normal subjects, subpressor and pressor doses of norepinephrine (10 ng/kg/min and 50 ng/kg/min, respectively) were infused for 1 hour. In five normal subjects, 60-degree head-up tilting was performed for 20 minutes. After norepinephrine infusion, plasma kinin levels were decreased significantly (p less than 0.01) with the subpressor dose of norepinephrine and were further decreased (p less than 0.01) with the pressor dose. Plasma ACE activity, however, showed no significant changes following these infusions. During the tilting, plasma kinin levels decreased significantly (p less than 0.01), whereas plasma norepinephrine levels increased significantly (p less than 0.01). From these results, the assumption of elevated levels in plasma endogenous or exogenous norepinephrine leads to a decrease in plasma kinin levels; this suggests that these two systems may be closely interrelated.
为研究血浆激肽与交感神经系统之间的关系，我们测定了正常受试者的血浆激肽、去甲肾上腺素和血管紧张素I转换酶（ACE：激肽酶II）活性。在6名正常受试者中，分别以低于升压剂量和升压剂量的去甲肾上腺素（分别为10 ng/kg/min和50 ng/kg/min）输注1小时。在5名正常受试者中，进行60度头高位倾斜20分钟。去甲肾上腺素输注后，低于升压剂量的去甲肾上腺素使血浆激肽水平显著降低（p<0.01），升压剂量使其进一步降低（p<0.01）。然而，这些输注后血浆ACE活性无显著变化。在倾斜过程中，血浆激肽水平显著降低（p<0.01），而血浆去甲肾上腺素水平显著升高（p<0.01）。根据这些结果，内源性或外源性去甲肾上腺素血浆水平升高会导致血浆激肽水平降低，这表明这两个系统可能密切相关。
