Jończyk-Matysiak Ewa, Weber-Dąbrowska Beata, Żaczek Maciej, Międzybrodzki Ryszard, Letkiewicz Sławomir, Łusiak-Szelchowska Marzanna, Górski Andrzej
Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences Wroclaw, Poland.
Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland.
Front Microbiol. 2017 Feb 8;8:164. doi: 10.3389/fmicb.2017.00164. eCollection 2017.
is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of phages, and there have been numerous studies on phage killing of , but no data are available on phage application specifically in acne treatment. In this review, we have summarized the current knowledge on the phages active against described so far and their potential application in the treatment of acne associated with . The treatment of acne with phages may be important in order to reduce the overuse of antibiotics, which are currently the main acne treatment. However, more detailed studies are first needed to understand phage functioning in the skin microbiome and the possibility to use phages to combat .
与化脓性皮肤感染相关，它给患者和医生都带来了全球性问题。寻常痤疮因其慢性特征、治疗困难以及对患者生活质量的巨大影响，仍然是一个问题。由于该疾病病程慢性，治疗持续时间长且往往无效。目前有关于噬菌体分离的数据，并且已经有许多关于噬菌体杀灭……的研究，但尚无关于噬菌体专门用于痤疮治疗的应用数据。在本综述中，我们总结了目前关于迄今所描述的对……有活性的噬菌体的知识及其在治疗与……相关的痤疮中的潜在应用。用噬菌体治疗痤疮对于减少目前作为主要痤疮治疗手段的抗生素的过度使用可能很重要。然而，首先需要更详细的研究来了解噬菌体在皮肤微生物群中的作用以及使用噬菌体对抗……的可能性。
