Krysko Kristen M, Sundaram Arun N E
Division of Neurology, University of Toronto , Toronto, Ontario, Canada.
Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Visual Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Neuroophthalmology. 2016 Sep 23;41(1):30-34. doi: 10.1080/01658107.2016.1224256. eCollection 2017 Feb.
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) can rarely cause alternate-sided homonymous hemianopia due to stroke-like episodes involving the occipital lobes, as reported in three previously published cases. The authors report an interesting case of a 16-year-old presenting with myoclonic epilepsy due to MELAS with the rare ND3 mitochondrial mutation T10191C, with recurrent alternate-sided homonymous hemianopia. Visual field and corresponding magnetic resonance imaging (MRI) findings are presented. To the authors' knowledge, this is the first report of recurrent alternate-sided homonymous hemianopia in MELAS with documented visual field and MRI findings with resolution between each episode.
线粒体脑肌病伴乳酸酸中毒和卒中样发作（MELAS）很少会因累及枕叶的卒中样发作而导致交替性同向性偏盲，此前已有3例病例报道。作者报告了1例有趣的病例，一名16岁青少年因MELAS伴罕见的ND3线粒体突变T10191C出现肌阵挛性癫痫，并伴有反复交替性同向性偏盲。文中展示了视野及相应的磁共振成像（MRI）结果。据作者所知，这是首例有记录的视野和MRI结果且发作间期症状可缓解的MELAS反复交替性同向性偏盲病例报告。
