一种新型且可能具有益生元特性的α-胞苷衍生物。
A new and potentially prebiotic α-cytidine derivative.
作者信息
Tsanakopoulou Maria, Xu Jianfeng, Bond Andrew D, Sutherland John D
机构信息
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CB2 0QH, UK.
Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.
出版信息
Chem Commun (Camb). 2017 Mar 16;53(23):3327-3329. doi: 10.1039/c7cc00693d.
Abstract
A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.
摘要
一种新的α-胞苷衍生物由核糖氨基恶唑啉与二氰基乙炔的益生元反应合成。通过X射线衍射确定了产物的四环结构，随后发现了一条适合大规模合成的通往该产物的替代六步合成途径。
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