Fudman E J, Till G O, Fox I H
Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
J Rheumatol. 1987 Aug;14(4):686-91.
Eleven patients with rheumatoid arthritis (RA) were treated with intraarticular deferoxamine or placebo to test the hypothesis that iron chelation decreased hydroxyl radical mediated lipid peroxidation in RA. Intraarticular administration of deferoxamine 100 mg resulted in predominantly systemic effects with decreased serum ferritin and decreased serum levels of lipid peroxidation products. Similar changes were not detected in synovial fluid at this dose. Iron chelation with deferoxamine may provide a novel approach to preventing tissue injury in RA by inhibiting hydroxyl radical production and lipid peroxidation.
11名类风湿性关节炎（RA）患者接受了关节内去铁胺或安慰剂治疗，以验证铁螯合作用可降低RA中羟基自由基介导的脂质过氧化这一假设。关节内注射100mg去铁胺主要产生全身效应，表现为血清铁蛋白降低以及脂质过氧化产物的血清水平降低。在此剂量下，滑液中未检测到类似变化。去铁胺进行铁螯合作用可能通过抑制羟基自由基生成和脂质过氧化为预防RA中的组织损伤提供一种新方法。
