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细胞朊蛋白在神经元中α-突触核蛋白运输中的作用。

Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.

机构信息

Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona, Baldiri Reixac 15-21, E-08028, Barcelona, Spain.

Department of Cell Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.

出版信息

Mol Neurobiol. 2018 Mar;55(3):1847-1860. doi: 10.1007/s12035-017-0451-4. Epub 2017 Feb 22.

DOI:10.1007/s12035-017-0451-4
PMID:28229331
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5840251/
Abstract

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrP-overexpressing mice. In addition, α-synuclein binds strongly on PrP-expressing cells, suggesting a role in modulating the effect of α-synuclein fibrils.

摘要

细胞朊病毒蛋白由 Prnp 基因编码，据报道它是β-淀粉样蛋白的受体。它们的相互作用是β-淀粉样蛋白寡聚物产生神经毒性作用的必要条件。在这项研究中，我们旨在探索细胞朊病毒蛋白是否参与α-突触核蛋白的传播。结果表明，细胞朊病毒蛋白的表达对于α-突触核蛋白的传播不是必需的。然而，尽管α-突触核蛋白的病理性传播可以在没有 Prnp 的情况下发生，但在 PrP 过表达的小鼠中，α-突触核蛋白的传播速度更快。此外，α-突触核蛋白在表达 PrP 的细胞上强烈结合，提示其在调节α-突触核蛋白纤维的作用中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/c4c69730a1df/12035_2017_451_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/6858233d504d/12035_2017_451_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/a2b2fbb7da66/12035_2017_451_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/189029348f41/12035_2017_451_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/1e7da4fbec0f/12035_2017_451_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/e1aa6db0e11d/12035_2017_451_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/c4c69730a1df/12035_2017_451_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/6858233d504d/12035_2017_451_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/a2b2fbb7da66/12035_2017_451_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/189029348f41/12035_2017_451_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/1e7da4fbec0f/12035_2017_451_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/e1aa6db0e11d/12035_2017_451_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6201/5840251/c4c69730a1df/12035_2017_451_Fig6_HTML.jpg

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