Lin Ren, Yan Junjie, Liu Weidong, Fan Tonghai, Tang Liujun
Department of Stomatology, The People's Hospital of Lishui, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China.
J Cancer Res Ther. 2016 Dec;12(Supplement):C256-C259. doi: 10.4103/0973-1482.200751.
The purpose of this meta-analysis was to evaluate the predictive value of cervical lymph node metastasis through sentinel lymph node biopsy (SLNB) in patients with oral cancer.
Two authors independently searched the databases of PubMed, Cochrane central register of controlled trials, EMBASE, and CNKI to find the potential suitable diagnostic study related to SLNB. The diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (-LR), diagnostic odds ratio (DOR) were pooled by Meta-DiSc1.4 software. The publication bias was assessed by funnel plot and line regression test.
After electronic searching the related databases, we finally included twenty diagnostic studies. The pooled sensitivity, specificity, +LR, and DOR were 0.91 (95% confidence interval [CI]: 0.88-0.94), 1.00 (95% CI: 0.99-1.00), 35.52 (95% CI: 19.19-65.75), and 323.50 (95% CI: 148.27-705.83), respectively, with fixed-effect model. Moreover, the pooled -LR was 0.13 (95% CI: 0.07-0.23) by random-effect model. The area under the summary receiver operating characteristic curve of SLNB for cervical lymph node metastasis was 0.99.
SLNB had very high sensitivity and specificity for productizing cervical lymph node metastasis in oral cancer patients.
本荟萃分析的目的是评估前哨淋巴结活检（SLNB）对口腔癌患者颈部淋巴结转移的预测价值。
两位作者独立检索了PubMed、Cochrane对照试验中央注册库、EMBASE和CNKI数据库，以寻找与SLNB相关的潜在合适诊断研究。通过Meta-DiSc1.4软件汇总诊断敏感性、特异性、阳性似然比（+LR）、阴性似然比（-LR）、诊断比值比（DOR）。通过漏斗图和线性回归检验评估发表偏倚。
在对相关数据库进行电子检索后，我们最终纳入了20项诊断研究。采用固定效应模型时，汇总敏感性、特异性、+LR和DOR分别为0.91（95%置信区间[CI]：0.88 - 0.94）、1.00（95%CI：0.99 - 1.00）、35.52（95%CI：19.19 - 65.75）和323.50（95%CI：148.27 - 705.83）。此外，采用随机效应模型时，汇总-LR为0.13（95%CI：0.07 - 0.23）。SLNB用于颈部淋巴结转移的汇总受试者工作特征曲线下面积为0.99。
SLNB对口腔癌患者颈部淋巴结转移的诊断具有非常高的敏感性和特异性。
Zotero 插件