• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

环轮烷卡明 A 和 A，来自刚果弯管安息香藤本植物的含氧桥萘基异喹啉二聚体。

Cyclombandakamines A and A, Oxygen-Bridged Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Liana.

机构信息

Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.

Faculté des Sciences, Université de Kinshasa , B.P. 202 Kinshasa XI, Democratic Republic of the Congo.

出版信息

Org Lett. 2017 Mar 17;19(6):1342-1345. doi: 10.1021/acs.orglett.7b00209. Epub 2017 Feb 23.

DOI:10.1021/acs.orglett.7b00209
PMID:28231014
Abstract

Cyclombandakamines A (1) and A (2), both with an unprecedented pyrane-cyclohexenone-dihydrofuran sequence and six stereocenters and two chiral axes, are the first oxygen-bridged dimeric naphthylisoquinoline alkaloids. They were isolated from the leaves of an as yet unidentified Congolese Ancistrocladus species. Their stereostructures were established by spectroscopic, chemical, and chiroptical methods in combination with DFT and TDDFT calculations. They apparently originate from a cascade of oxidative cyclization reactions of "open-chain" naphthylisoquinoline dimers and exhibit significant antiprotozoal activities.

摘要

环棒木卡明 A（1）和 A（2）均具有前所未有的吡喃-环己烯酮-二氢呋喃序列和六个立体中心以及两个手性轴，是第一个氧桥联二聚体萘基异喹啉生物碱。它们从一种尚未鉴定的刚果Ancistrocladus 物种的叶子中分离出来。它们的立体结构通过光谱、化学和旋光方法以及 DFT 和 TDDFT 计算相结合来确定。它们显然源自“开链”萘基异喹啉二聚体的级联氧化环化反应，并表现出显著的抗原生动物活性。

相似文献

1
Cyclombandakamines A and A, Oxygen-Bridged Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Liana.环轮烷卡明 A 和 A，来自刚果弯管安息香藤本植物的含氧桥萘基异喹啉二聚体。
Org Lett. 2017 Mar 17;19(6):1342-1345. doi: 10.1021/acs.orglett.7b00209. Epub 2017 Feb 23.
2
An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis.来自刚果藤本植物Ancistrocladus ealaensis 的一组异常广泛的七种环棒烷卡巴宁、桥联二聚体萘基异喹啉生物碱。
Sci Rep. 2019 Jul 8;9(1):9812. doi: 10.1038/s41598-019-46336-z.
3
Spirombandakamine A and Cyclombandakamines A and A, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Plant.来自一种刚果植物的具有抗原生动物活性的螺环班达卡明A以及环班达卡明A和A，多环萘基异喹啉二聚体
J Nat Prod. 2021 Apr 23;84(4):1335-1344. doi: 10.1021/acs.jnatprod.1c00063. Epub 2021 Apr 12.
4
Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese Ancistrocladus species.曼达卡明 A 和 B，一种来自刚果弯花安息香的非对称偶联的萘基异喹啉生物碱。
Org Lett. 2013 Jun 7;15(11):2590-3. doi: 10.1021/ol4005883. Epub 2013 May 13.
5
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.刚果钩枝藤碱A-D，源自刚果钩枝藤的新型萘基异喹啉生物碱。
J Nat Prod. 2002 Aug;65(8):1096-101. doi: 10.1021/np010622d.
6
Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius.从羊角拗中提取的高选择性抗疟原虫萘基异喹啉生物碱。
Phytochemistry. 2013 Jul;91:220-8. doi: 10.1016/j.phytochem.2012.02.017. Epub 2012 Mar 27.
7
Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line.乔兹利波米内 A 和 B，来自刚果木质藤本植物Ancistrocladus ileboensis 的萘基异喹啉二聚体，具有针对人胰腺癌细胞系 PANC-1 的抗奢侈化活性。
J Nat Prod. 2017 Oct 27;80(10):2807-2817. doi: 10.1021/acs.jnatprod.7b00650. Epub 2017 Oct 18.
8
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.钩枝藤宁碱A，首个5,3'-偶联萘基异喹啉生物碱，以及另外两种来自新描述物种坦桑尼亚钩枝藤的5,8'-相连相关化合物。
J Nat Prod. 2003 Sep;66(9):1159-65. doi: 10.1021/np030077b.
9
Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species ancistrocladusbenomensis.从“新”植物物种Ancistrocladus benomensis中提取的安氏苯诺明a，首个在3位甲基处被氧化的萘基异喹啉，以及相关的5,1'-偶联生物碱。
J Nat Prod. 2004 Dec;67(12):2058-62. doi: 10.1021/np0497651.
10
Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius.双岸千里光碱 A-E，来自中国植物山香圆的二聚萘基异喹啉生物碱，具有三个手性联苯轴。
Chemistry. 2010 Apr 12;16(14):4206-16. doi: 10.1002/chem.200903247.

引用本文的文献

1
Michellamines A and A, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese liana and their antiausterity activities against pancreatic cancer cells.米氏胺A和A，以及从一种刚果藤本植物中提取的其他单聚和二聚萘基异喹啉生物碱及其对胰腺癌细胞的抗增殖活性。
RSC Adv. 2018 Jan 31;8(10):5243-5254. doi: 10.1039/c8ra00363g. eCollection 2018 Jan 29.
2
Ancistrobreveines A-D and related dehydrogenated naphthylisoquinoline alkaloids with antiproliferative activities against leukemia cells, from the West African liana .来自西非藤本植物的钩枝藤碱A-D及具有抗白血病细胞增殖活性的相关脱氢萘基异喹啉生物碱。
RSC Adv. 2019 May 20;9(28):15738-15748. doi: 10.1039/c9ra03105g.
3
Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B and B, and related 5,8'-coupled monomeric alkaloids, ikelacongolines A-D, from a Congolese liana.
从一种刚果藤本植物中提取的抗原生动物二聚萘基异喹啉类化合物、姆班达卡胺B和B，以及相关的5,8'-偶联单体生物碱、伊凯拉刚果碱A-D。
RSC Adv. 2019 Apr 16;9(21):12034-12046. doi: 10.1039/c9ra01784d. eCollection 2019 Apr 12.
4
Antimalarial Natural Products.抗疟天然产物。
Prog Chem Org Nat Prod. 2022;117:1-106. doi: 10.1007/978-3-030-89873-1_1.
5
A Conversation with Gerhard Bringmann.与格哈德·布林曼的一次对话。
ACS Cent Sci. 2020 Aug 26;6(8):1248-1252. doi: 10.1021/acscentsci.0c00388. Epub 2020 Aug 6.
6
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019.从非洲药用植物中提取的抗疟化合物的潜力：2013 年至 2019 年药理学评估综述。
Malar J. 2020 May 18;19(1):183. doi: 10.1186/s12936-020-03231-7.
7
An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis.来自刚果藤本植物Ancistrocladus ealaensis 的一组异常广泛的七种环棒烷卡巴宁、桥联二聚体萘基异喹啉生物碱。
Sci Rep. 2019 Jul 8;9(1):9812. doi: 10.1038/s41598-019-46336-z.