Institute of Organic Chemistry, University of Würzburg, Würzburg, Germany.
Phytochemistry. 2013 Jul;91:220-8. doi: 10.1016/j.phytochem.2012.02.017. Epub 2012 Mar 27.
Naphthylisoquinoline alkaloids, named ancistectorine A1, N-methylancistectorine A1, ancistectorine A2, 5-epi-ancistectorine A2, ancistectorine A3, ancistectorine B1, and ancistectorine C1, have been isolated from twigs of the Chinese plant Ancistrocladus tectorius. The structural elucidation succeeded by chemical, spectroscopic, and chiroptical methods. Three of these compounds exhibited excellent, and specific, antiplasmodial activities, comparable with that of the as yet most active representative, dioncophylline C. Moreover, the antitumoral activities of two of the main alkaloids in this species was tested.
从中国植物头花千金藤（Ancistrocladus tectorius）的嫩枝中分离得到了萘基异喹啉生物碱Ancistectorine A1、N-甲基Ancistectorine A1、Ancistectorine A2、5-表-Ancistectorine A2、Ancistectorine A3、Ancistectorine B1 和 Ancistectorine C1。通过化学、光谱和手性光学方法成功地进行了结构阐明。其中三种化合物表现出优异的、特异性的抗疟原虫活性，可与迄今为止最有效的代表物 Dioncophylline C 相媲美。此外，还测试了该物种两种主要生物碱的抗肿瘤活性。
