小鼠钠钾ATP酶α亚基的染色体介导转移赋予哇巴因抗性。
Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance.
作者信息
Fallows D, Kent R B, Nelson D L, Emanuel J R, Levenson R, Housman D E
机构信息
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Mol Cell Biol. 1987 Aug;7(8):2985-7. doi: 10.1128/mcb.7.8.2985-2987.1987.
Abstract
We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.
摘要
我们将小鼠NIH 3T3中期染色体转入猴CV-1细胞，以研究啮齿动物和灵长类动物细胞对哇巴因的不同敏感性。在16个耐哇巴因的转染细胞中，检测到了小鼠钠钾ATP酶α1亚基基因，这表明啮齿动物和灵长类动物α1亚基之间的结构差异决定了对哇巴因的不同敏感性。
Zotero 插件