Dunwiddie T V, Alford C
Department of Pharmacology, University of Colorado, Health Sciences Center, Denver 80262.
Neuropharmacology. 1987 Sep;26(9):1267-73. doi: 10.1016/0028-3908(87)90086-4.
The electrophysiological effects of phencyclidine were examined in the CA region of slice preparations of the hippocampus of the rat. The only direct effects of phencyclidine on monosynaptic transmission in the Schaffer collateral/commissural input to the CA region were local anesthetic-like actions, that were observed at concentration greater than or equal to 50 microM, and were characterized by decreases in the amplitude of both orthodromically- and antidromically-evoked potentials. However, phencyclidine, at concentrations greater than 0.5 microM, increased the apparent sensitivity of slices to perfusion with norepinephrine (NE), such that a previously subthreshold concentration of NE significantly increased the magnitude of the population spike response through an action at beta-adrenergic receptors. This action of phencyclidine appears to reflect its ability to block the high affinity uptake of NE into nerve terminals in the slice preparation. Because these responses were observed at concentrations of phencyclidine which are found in the brains of abusers of phencyclidine, they may play a significant role in the overall neuropharmacological response to phencyclidine.
研究了苯环利定对大鼠海马脑片CA区的电生理效应。苯环利定对CA区Schaffer侧支/连合纤维输入的单突触传递的唯一直接效应是局部麻醉样作用，这种作用在浓度大于或等于50微摩尔时可观察到，其特征是顺向和逆向诱发电位的幅度降低。然而，浓度大于0.5微摩尔的苯环利定增加了脑片对去甲肾上腺素（NE）灌注的表观敏感性，以至于先前阈下浓度的NE通过作用于β-肾上腺素能受体显著增加了群体峰电位反应的幅度。苯环利定的这种作用似乎反映了其阻断脑片中NE高亲和力摄取进入神经末梢的能力。由于在苯环利定滥用者的大脑中发现的苯环利定浓度下观察到了这些反应，它们可能在对苯环利定的整体神经药理学反应中起重要作用。
