McGill University & Douglas Mental Health University Institute, McGill Group for Suicide Studies, Montreal, Québec, Canada.
Université Montpellier I, Montpellier, France & Montpellier Academic Hospital (CHU), Department of psychiatry, Montpellier, France & Inserm, U1061 Montpellier, France.
Psychiatry Res Neuroimaging. 2017 Apr 30;262:47-54. doi: 10.1016/j.pscychresns.2017.02.002. Epub 2017 Feb 10.
Reduced size of the corpus callosum (CC) has been associated with bipolar disorders and suicidality. Here, we aimed at investigating the relative independence of these associations in a large sample of patients. Two samples of males and females totaling 209 euthymic participants were recruited, including 72 patients with a major depressive disorder, 64 with bipolar disorders and 73 healthy controls. Among patients, 61 had a lifetime history of suicide attempt and 75 had none. Structural scans were acquired with 1.5T magnetic resonance imaging. Surface-based morphometry (Freesurfer) analysis was used to compute the volumes of the CC. In the whole sample, there was a significant reduction in the volume of mid-anterior, central, and mid-posterior (all p<0.008) CC in bipolar patients independently from suicidality, with medium effect sizes between unipolar and bipolar patients (Cohen's d between 0.46 and 0.62). In contrast, suicide attempters did not differ from non-attempters. This significant association between CC volumes and bipolar disorders was mainly found in the male sample, while a trend was found in the female sample. Within each patient group, medication had no major effect. Our study adds to the growing body of evidence linking corpus callosum alterations and bipolar disorders.
胼胝体体积减小与双相情感障碍和自杀意念有关。在此，我们旨在通过对大量患者样本的研究，探究这些关联的相对独立性。共招募了两个男女混合样本，共 209 名病情稳定的参与者，包括 72 名单相抑郁障碍患者、64 名双相情感障碍患者和 73 名健康对照者。在患者中，61 人有自杀未遂史，75 人无自杀未遂史。采用 1.5T 磁共振成像采集结构扫描。利用基于表面的形态计量学（Freesurfer）分析计算胼胝体体积。在整个样本中，与自杀意念无关，双相情感障碍患者的前中部、中央部和后中部胼胝体体积均显著减小（均 p<0.008），且与单相抑郁障碍患者相比，双相情感障碍患者的中脑体积较小（Cohen's d 在 0.46 到 0.62 之间）。相比之下，自杀未遂者与非自杀未遂者无差异。在男性样本中发现了胼胝体体积与双相情感障碍之间的这种显著关联，而在女性样本中则存在一种趋势。在每个患者组中，药物治疗均无明显影响。我们的研究为胼胝体改变与双相情感障碍之间的关联提供了更多证据。
