Uversky Vladimir N
Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute; Morsani College of Medicine; University of South Florida; Tampa, FL USA; Institute for Biological Instrumentation; Russian Academy of Sciences; Pushchino, Russia; Biology Department; Faculty of Science; King Abdulaziz University; Jeddah, Kingdom of Saudi Arabia.
Intrinsically Disord Proteins. 2014 Dec 12;2(1):e970499. doi: 10.4161/21690693.2014.970499. eCollection 2014.
This review opens a new series entitled "Unreported intrinsic disorder in proteins." The goal of this series is to bring attention of researchers to an interesting phenomenon of missed (or overlooked, or ignored, or unreported) disorder. This series serves as a companion to "Digested Disorder" which provides a quarterly review of papers on intrinsically disordered proteins (IDPs) found by standard literature searches. The need for this alternative series results from the observation that there are numerous publications that describe IDPs (or hybrid proteins with ordered and disordered regions) yet fail to recognize many of the key discoveries and publications in the IDP field. By ignoring the body of work on IDPs, such publications often fail to relate their findings to prior discoveries or fail to explore the obvious implications of their work. Thus, the goal of this series is not only to review these very interesting and important papers, but also to point out how each paper relates to the IDP field and show how common tools in the IDP field can readily take the findings in new directions or provide a broader context for the reported findings.
本综述开启了一个名为“蛋白质中未报道的内在无序”的新系列。本系列的目标是让研究人员关注一个有趣的现象,即遗漏(或忽视、或忽略、或未报道)的无序现象。本系列作为“消化无序”的补充,后者对通过标准文献检索发现的关于内在无序蛋白质(IDP)的论文进行季度综述。设立这个替代系列的必要性源于这样一个观察结果:有许多出版物描述了IDP(或具有有序和无序区域的杂合蛋白),但未能认识到IDP领域的许多关键发现和出版物。由于忽视了关于IDP的大量工作,此类出版物往往无法将其研究结果与先前的发现联系起来,或者无法探讨其工作的明显含义。因此,本系列的目标不仅是综述这些非常有趣且重要的论文,还指出每篇论文与IDP领域的关系,并展示IDP领域的常用工具如何能够轻易地将研究结果导向新的方向,或为所报道的研究结果提供更广阔的背景。