Draijer Christina, Peters-Golden Marc
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109-5642, USA.
Curr Allergy Asthma Rep. 2017 Feb;17(2):12. doi: 10.1007/s11882-017-0681-6.
The role of alveolar macrophages in innate immune responses has long been appreciated. Here, we review recent studies evaluating the participation of these cells in allergic inflammation.
Immediately after allergen exposure, monocytes are rapidly recruited from the bloodstream and serve to promote acute inflammation. By contrast, resident alveolar macrophages play a predominantly suppressive role in an effort to restore homeostasis. As inflammation becomes established after repeated exposures, alveolar macrophages can polarize across a continuum of activation phenotypes, losing their suppressive functions and gaining pathogenic functions. Future research should focus on the diverse roles of monocytes/macrophages during various types and phases of allergic inflammation. These properties could lead us to new therapeutic opportunities.
肺泡巨噬细胞在固有免疫反应中的作用早已为人所知。在此，我们综述近期评估这些细胞参与变应性炎症的研究。
变应原暴露后，单核细胞迅速从血流中募集，促进急性炎症。相比之下，驻留的肺泡巨噬细胞主要发挥抑制作用以恢复内环境稳定。随着反复暴露后炎症确立，肺泡巨噬细胞可在一系列激活表型中极化，失去其抑制功能并获得致病性功能。未来研究应聚焦于单核细胞/巨噬细胞在变应性炎症不同类型和阶段中的多样作用。这些特性可能为我们带来新的治疗机会。
